Sökning: onr:"swepub:oai:DiVA.org:liu-121751" >
Concurrent loss of ...
Concurrent loss of co-stimulatory molecules and functional cytokine secretion attributes leads to proliferative senescence of CD8(+) T cells in HIV/TB co-infection
-
- Saeidi, Alireza (författare)
- University of Malaya, Malaysia
-
- Chong, Yee K. (författare)
- University of Malaya, Malaysia
-
- Yong, Yean K. (författare)
- University of Malaya, Malaysia
-
visa fler...
-
- Tan, Hong Y. (författare)
- University of Malaya, Malaysia
-
- Barathan, Muttiah (författare)
- University of Malaya, Malaysia
-
- Rajarajeswaran, Jayakumar (författare)
- University of Malaya, Malaysia
-
- Sabet, Negar S. (författare)
- SEGi University, Malaysia
-
- Sekaran, Shamala D. (författare)
- University of Malaya, Malaysia
-
- Ponnampalavanar, Sasheela (författare)
- University of Malaya, Malaysia
-
- Che, Karlhans F. (författare)
- Karolinska Institutet
-
- Velu, Vijayakumar (författare)
- Emory Vaccine Centre, GA 30329 USA
-
- Kamarulzaman, Adeeba (författare)
- University of Malaya, Malaysia
-
- Larsson, Marie (författare)
- Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten
-
- Shankar, Esaki M. (författare)
- University of Malaya, Malaysia; University of Malaya, Malaysia; University of Malaya, Malaysia
-
visa färre...
-
(creator_code:org_t)
- ACADEMIC PRESS INC ELSEVIER SCIENCE, 2015
- 2015
- Engelska.
-
Ingår i: Cellular Immunology. - : ACADEMIC PRESS INC ELSEVIER SCIENCE. - 0008-8749 .- 1090-2163. ; 297:1, s. 19-32
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- The role of T-cell immunosenescence and functional CD8(+) T-cell responses in HIV/TB co-infection is unclear. We examined and correlated surrogate markers of HIV disease progression with immune activation, immunosenescence and differentiation using T-cell pools of HIV/TB co-infected, HIV-infected and healthy controls. Our investigations showed increased plasma viremia and reduced CD4/CD8 T-cell ratio in HIV/TB co-infected subjects relative to HIV-infected, and also a closer association with changes in the expression of CD38, a cyclic ADP ribose hydrolase and CD57, which were consistently expressed on late-senescent CD8(+) T cells. Up-regulation of CD57 and CD38 were directly proportional to lack of co-stimulatory markers on CD8(+) T cells, besides diminished expression of CD127 (IL-7R alpha) on CD57(+)CD4(+) T cells. Notably, intracellular IFN-gamma, perforin and granzyme B levels in HIV-specific CD8(+) T cells of HIV/TB co-infected subjects were diminished. Intracellular CD57 levels in HIV gag p24-specific CD8(+) T cells were significantly increased in HIV/TB co-infection. We suggest that HIV-TB co-infection contributes to senescence associated with chronic immune activation, which could be due to functional insufficiency of CD8(+) T cells. (C) 2015 Elsevier Inc. All rights reserved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Co-stimulation; HIV/TB co-infection; Immune activation; Immunosenescence; T-cell activation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Saeidi, Alireza
-
Chong, Yee K.
-
Yong, Yean K.
-
Tan, Hong Y.
-
Barathan, Muttia ...
-
Rajarajeswaran, ...
-
visa fler...
-
Sabet, Negar S.
-
Sekaran, Shamala ...
-
Ponnampalavanar, ...
-
Che, Karlhans F.
-
Velu, Vijayakuma ...
-
Kamarulzaman, Ad ...
-
Larsson, Marie
-
Shankar, Esaki M ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
- Artiklar i publikationen
-
Cellular Immunol ...
- Av lärosätet
-
Linköpings universitet
-
Karolinska Institutet