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  • Frost Bellgowan, JulieLaureate Institute Brain Research, OK USA (författare)

A Neural Substrate for Behavioral Inhibition in the Risk for Major Depressive Disorder

  • Artikel/kapitelEngelska2015

Förlag, utgivningsår, omfång ...

  • ELSEVIER SCIENCE BV,2015
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-122434
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-122434URI
  • https://doi.org/10.1016/j.jaac.2015.08.001DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies|Warren Foundation
  • Objective: Behavioral inhibition (BI) is an early developing trait associated with cautiousness and development of clinical depression and anxiety. Little is known about the neural basis of BI and its predictive importance concerning risk for internalizing disorders. We looked at functional connectivity of the default-mode network (DMN) and salience network (SN), given their respective roles in self-relational and threat processing, in the risk for internalizing disorders, with an emphasis on determining the functional significance of these networks for BI. Method: We used functional magnetic resonance imaging to scan, during the resting state, children and adolescents 8 to 17 years of age who were either at high familial risk (HR; n = 16) or low familial risk (LR; n = 18) for developing clinical depression and/or anxiety. Whole-brain DMN and SN functional connectivity were estimated for each participant and compared across groups. We also compared the LR and HR groups on levels of BI and anxiety, and incorporated these data into follow-up neurobehavioral correlation analyses. Results: The HR group, relative to the LR group, showed significantly decreased DMN connectivity with the ventral striatum and bilateral sensorimotor cortices. Within the HR group, trait BI increased as DMN connectivity with the ventral striatum and sensorimotor cortex decreased. The HR and LR groups did not differ with respect to SN connectivity. Conclusion: Our findings show, in the risk for internalizing disorders, a negative functional relation between brain regions supporting self-relational processes and reward prediction. These findings represent a potential neural substrate for behavioral inhibition in the risk for clinical depression and anxiety.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Molfese, PeterHaskins Labs Inc, CT USA (författare)
  • Marx, MichaelStanford University, CA 94305 USA (författare)
  • Thomason, MoriahWayne State University, MI USA (författare)
  • Glen, DanielNIMH, MD 20892 USA (författare)
  • Santiago, JessicaLaureate Institute Brain Research, OK USA (författare)
  • Gotlib, Ian H.Stanford University, CA 94305 USA (författare)
  • Drevets, Wayne C.Laureate Institute Brain Research, OK USA; Janssen Pharmaceut, Belgium (författare)
  • Hamilton, Paul J.Linköpings universitet,Centrum för social och affektiv neurovetenskap (CSAN),Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Laureate Institute Brain Research, OK USA(Swepub:liu)pauha77 (författare)
  • Laureate Institute Brain Research, OK USAHaskins Labs Inc, CT USA (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of the American Academy of Child and Adolescent Psychiatry: ELSEVIER SCIENCE BV54:10, s. 841-8480890-85671527-5418

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