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Sökning: onr:"swepub:oai:DiVA.org:liu-122778" > N-terminal pro-B-ty...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004967naa a2200505 4500
001oai:DiVA.org:liu-122778
003SwePub
008151123s2015 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1227782 URI
0247 a https://doi.org/10.1097/ALN.00000000000007282 DOI
040 a (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Potgieter, Danielleu University of KwaZulu Natal, South Africa4 aut
2451 0a N-terminal pro-B-type Natriuretic Peptides Prognostic Utility Is Overestimated in Meta-analyses Using Study-specific Optimal Diagnostic Thresholds
264 1b LIPPINCOTT WILLIAMS and WILKINS,c 2015
338 a print2 rdacarrier
500 a Funding Agencies|CLS Behring Biotherapies for Life (Vienna, Austria); Astra Zeneca (Vienna, Austria); Boehringer Ingelheim (Ingelheim, Germany); CLS Behring Biotherapies for Life; Novo Nordisk Pharma GmbH (Vienna, Austria)
520 a Background:N-terminal fragment B-type natriuretic peptide (NT-proBNP) prognostic utility is commonly determined post hoc by identifying a single optimal discrimination threshold tailored to the individual study population. The authors aimed to determine how using these study-specific post hoc thresholds impacts meta-analysis results. Methods: The authors conducted a systematic review of studies reporting the ability of preoperative NT-proBNP measurements to predict the composite outcome of all-cause mortality and nonfatal myocardial infarction at 30 days after noncardiac surgery. Individual patient-level data NT-proBNP thresholds were determined using two different methodologies. First, a single combined NT-proBNP threshold was determined for the entire cohort of patients, and a meta-analysis conducted using this single threshold. Second, study-specific thresholds were determined for each individual study, with meta-analysis being conducted using these study-specific thresholds. Results: The authors obtained individual patient data from 14 studies (n = 2,196). Using a single NT-proBNP cohort threshold, the odds ratio (OR) associated with an increased NT-proBNP measurement was 3.43 (95% CI, 2.08 to 5.64). Using individual study-specific thresholds, the OR associated with an increased NT-proBNP measurement was 6.45 (95% CI, 3.98 to 10.46). In smaller studies (less than100 patients) a single cohort threshold was associated with an OR of 5.4 (95% CI, 2.27 to 12.84) as compared with an OR of 14.38 (95% CI, 6.08 to 34.01) for study-specific thresholds. Conclusions:Post hoc identification of study-specific prognostic biomarker thresholds artificially maximizes biomarker predictive power, resulting in an amplification or overestimation during meta-analysis of these results. This effect is accentuated in small studies.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
7001 a Simmers, Daleu University of KwaZulu Natal, South Africa4 aut
7001 a Ryan, Lisau Greys Hospital, South Africa4 aut
7001 a Biccard, Bruce M.u University of KwaZulu Natal, South Africa4 aut
7001 a Lurati-Buse, Giovanna A.u University of Basel Hospital, Switzerland4 aut
7001 a Cardinale, Daniela M.u European Institute Oncol, Italy4 aut
7001 a Chong, Carol P. W.u Northern Hospital, Australia; University of Melbourne, Australia4 aut
7001 a Cnotliwy, Miloslawu Pomeranian Medical University, Poland4 aut
7001 a Farzi, Sylvia I.u Medical University of Graz, Austria4 aut
7001 a Jankovic, Radmilo J.u University of Nis, Serbia4 aut
7001 a Kwang Lim, Wenu Medical University of Graz, Austria4 aut
7001 a Mahla, Elisabethu Medical University of Graz, Austria4 aut
7001 a Manikandan, Ramaswamyu Stepping Hill Hospital, England4 aut
7001 a Oscarsson, Annau Linköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,Region Östergötland, ANOPIVA US4 aut0 (Swepub:liu)annos67
7001 a Phy, Michael P.u Texas Technical University, TX 79430 USA4 aut
7001 a Rajagopalan, Sriramu University of Aberdeen, Scotland; Aberdeen Royal Infirm, Scotland4 aut
7001 a Van Gaal, William J.u University of Melbourne, Australia4 aut
7001 a Waliszek, Mareku M Pirogow Prov Specialist Hospital, Poland4 aut
7001 a Rodseth, Reitze N.u University of KwaZulu Natal, South Africa; Cleveland Clin, OH 44106 USA4 aut
7102 a University of KwaZulu Natal, South Africab Greys Hospital, South Africa4 org
7730 t Anesthesiologyd : LIPPINCOTT WILLIAMS and WILKINSg 123:2, s. 264-271q 123:2<264-271x 0003-3022x 1528-1175
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-122778
8564 8u https://doi.org/10.1097/ALN.0000000000000728

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