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Rituximab for treat...
Rituximab for treatment of severe renal disease in ANCA associated vasculitis
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- Geetha, Duvuru (författare)
- Johns Hopkins University, Baltimore, MD, USA
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- Hruskova, Zdenka (författare)
- Charles University, Prague, Czech Republic
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- Segelmark, Mårten (författare)
- Linköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,Region Östergötland, Njurmedicinska kliniken US
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- Hogan, Jonathan (författare)
- Hospital of the University of Pennsylvania, Philadelphia, USA
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- Morgan, Matthew D (författare)
- University of Birmingham, UK
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- Cavero, Teresa (författare)
- Hospital 12 de Octubre, Madrid, Spain
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- Eriksson, Per, 1958- (författare)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Avdelningen för inflammation och infektion,Region Östergötland, Reumatologiska kliniken i Östergötland,Region Östergötland, Reumatologiska kliniken i Östergötland
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- Seo, Philip (författare)
- John Hopkins University, Baltimore, USA
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- Manno, Rebecca L (författare)
- John Hopkins University, Baltimore, USA
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- Dale, Jessica (författare)
- University of Birmingham, Birmingham, UK
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- Harper, Lorraine (författare)
- University of Birmingham, UK
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- Tesar, Vladimir (författare)
- Charles University, Prague, Czech Republic
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- Jayne, David Rw (författare)
- Addenbrooke's Hospital, Cambridge, UK
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(creator_code:org_t)
- 2015-05-19
- 2016
- Engelska.
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Ingår i: JN. Journal of Nephrology. - : Springer. - 1121-8428 .- 1724-6059. ; 29:2, s. 195-201
- Relaterad länk:
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http://pure-oai.bham...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BackgroundRituximab (RTX) is approved for remission induction in ANCA associated vasculitis (AAV). However, data on use of RTX in patients with severe renal disease is lacking.MethodsWe conducted a retrospective multi-center study to evaluate the efficacy and safety of RTX with glucocorticoids (GC) with and without use of concomitant cyclophosphamide (CYC) for remission induction in patients presenting with e GFR less than 20 ml/min/1.73 m2. We evaluated outcomes of remission at 6 months (6 M), renal recovery after acute dialysis at diagnosis, e-GFR rise at 6 M, patient and renal survival and adverse events.ResultsA total 37 patients met the inclusion criteria. The median age was 61 years. (55–73), 62 % were males, 78 % had new diagnosis and 59 % were MPO ANCA positive. The median (IQR) e-GFR at diagnosis was 13 ml/min/1.73 m2 (7–16) and 15 required acute dialysis. Eleven (30 %) had alveolar hemorrhage. Twelve (32 %) received RTX with GC, 25 (68 %) received RTX with GC and CYC and seventeen (46 %) received plasma exchange. The median (IQR) follow up was 973 (200–1656) days. Thirty two of 33 patients (97 %) achieved remission at 6 M and 10 of 15 patients (67 %) requiring dialysis recovered renal function. The median prednisone dose at 6 M was 6 mg/day. The mean (SD) increase in e-GFR at 6 months was 14.5 (22) ml/min/m2. Twelve patients developed ESRD during follow up. There were 3 deaths in the first 6 months. When stratified by use of concomitant CYC, there were no differences in baseline e GFR, use of plasmapheresis, RTX dosing regimen or median follow up days between the groups. No differences in remission, renal recovery ESRD or death were observed.ConclusionsThis study of AAV patients with severe renal disease demonstrates that the outcomes appear equivalent when treated with RTX and GC with or without concomitant CYC.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- Rituximab; Renal disease; ANCA vasculitis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Geetha, Duvuru
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Hruskova, Zdenka
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Segelmark, Mårte ...
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Hogan, Jonathan
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Morgan, Matthew ...
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Cavero, Teresa
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visa fler...
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Eriksson, Per, 1 ...
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Seo, Philip
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Manno, Rebecca L
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Dale, Jessica
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Harper, Lorraine
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Tesar, Vladimir
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Jayne, David Rw
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visa färre...
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Linköpings universitet