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Zinc-Triggered Hier...
Zinc-Triggered Hierarchical Self-Assembly of Fibrous Helix-Loop-Helix Peptide Superstructures for Controlled Encapsulation and Release
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- Aronsson, Christopher (författare)
- Linköpings universitet,Molekylär fysik,Tekniska fakulteten
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- Selegård, Robert (författare)
- Linköpings universitet,Institutionen för fysik, kemi och biologi,Tekniska fakulteten
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- Aili, Daniel (författare)
- Linköpings universitet,Molekylär fysik,Tekniska fakulteten
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(creator_code:org_t)
- 2016-09-15
- 2016
- Engelska.
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Ingår i: Macromolecules. - : AMER CHEMICAL SOC. - 0024-9297 .- 1520-5835. ; 49:18, s. 6997-7003
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Abstract
Ämnesord
Stäng
- We demonstrate a novel route for hierarchical self-assembly of sub-micrometer-sized peptide superstructures that respond to subtle changes in Zn2+ concentration. The self-assembly process is triggered by a specific folding-dependent coordination of Zn2+ by a de novo designed nonlinear helix-loop-helix peptide, resulting in a propagating fiber formation and formation of spherical superstructures. The superstructures further form larger assemblies that can be completely disassembled upon removal of Zn2+ or degradation of the nonlinear peptide. This flexible and reversible assembly strategy of the superstructures enables facile encapsulation of nanoparticles and drugs that can be released by means of different stimuli.
Ämnesord
- NATURVETENSKAP -- Kemi -- Polymerkemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Polymer Chemistry (hsv//eng)
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