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Estrogen Receptor a...
Estrogen Receptor a Promotes Breast Cancer by Reprogramming Choline Metabolism
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- Jia, Min (författare)
- Karolinska Institute, Sweden
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- Andreassen, Trygve (författare)
- Norwegian University of Science and Technology, Norway
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- Jensen, Lasse (författare)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Klinisk farmakologi,Karolinska Institute, Sweden
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- Frost Bathen, Tone (författare)
- Norwegian University of Science and Technology, Norway
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- Sinha, Indranil (författare)
- Karolinska Institutet
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- Gao, Hui (författare)
- Karolinska Institutet
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- Zhao, Chunyan (författare)
- Karolinska Institutet
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- Haldosen, Lars-Arne (författare)
- Karolinska Institutet
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- Cao, Yihai (författare)
- Karolinska Institute, Sweden
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- Girnita, Leonard (författare)
- Karolinska Institutet
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- Andreas Moestue, Siver (författare)
- Norwegian University of Science and Technology, Norway
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- Dahlman-Wright, Karin (författare)
- Karolinska Institutet
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(creator_code:org_t)
- AMER ASSOC CANCER RESEARCH, 2016
- 2016
- Engelska.
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Ingår i: Cancer Research. - : AMER ASSOC CANCER RESEARCH. - 0008-5472 .- 1538-7445. ; 76:19, s. 5634-5646
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Estrogen receptor alpha (ER alpha) is a key regulator of breast growth and breast cancer development. Here, we report how ER alpha impacts these processes by reprogramming metabolism in malignant breast cells. We employed an integrated approach, combining genome-wide mapping of chromatin-bound ER alpha with estrogeninduced transcript and metabolic profiling, to demonstrate that ER alpha reprograms metabolism upon estrogen stimulation, including changes in aerobic glycolysis, nucleotide and amino acid synthesis, and choline (Cho) metabolism. Cho phosphotransfse CHPT1, identified as a direct era-regulated gene, was required for estrogen- induced effects on Cho metabolism, including increased phosphatidylcholine synthesis. CHPT1 silencing inhibited anchorage- independent growth and cell proliferation, also suppressing early-stage metastasis of tamoxifen-resistant breast cancer cells in a zebrafish xenograft model. Our results showed that era promotes metabolic alterations in breast cancer cells mediated by its target CHPT1, which this study implicates as a candidate therapeutic target. (C) 2016 AACR.
Ämnesord
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
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- Av författaren/redakt...
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Jia, Min
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Andreassen, Tryg ...
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Jensen, Lasse
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Frost Bathen, To ...
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Sinha, Indranil
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Gao, Hui
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visa fler...
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Zhao, Chunyan
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Haldosen, Lars-A ...
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Cao, Yihai
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Girnita, Leonard
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Andreas Moestue, ...
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Dahlman-Wright, ...
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- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Cellbiologi
- Artiklar i publikationen
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Cancer Research
- Av lärosätet
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Linköpings universitet
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Karolinska Institutet