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Prognostic role of ...
Prognostic role of the lymph node ratio in node positive colorectal cancer: a meta-analysis
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- Zhang, Ming-Ran (författare)
- Sichuan University, Peoples R China; Sichuan University, Peoples R China; Sichuan University, Peoples R China
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- Xie, Tian-Hang (författare)
- Sichuan University, Peoples R China
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- Chi, Jun-Lin (författare)
- Sichuan University, Peoples R China
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- Li, Yuan (författare)
- Sichuan University, Peoples R China
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- Yang, Lie (författare)
- Sichuan University, Peoples R China
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- Yu, Yong-Yang (författare)
- Sichuan University, Peoples R China
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- Sun, Xiao-Feng (författare)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US,Sichuan University, Peoples R China
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- Zhou, Zong-Guang (författare)
- Sichuan University, Peoples R China
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(creator_code:org_t)
- 2016-09-20
- 2016
- Engelska.
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Ingår i: Oncotarget. - : IMPACT JOURNALS LLC. - 1949-2553. ; 7:45, s. 72898-72907
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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http://www.oncotarge...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The lymph node ratio (LNR) (i. e. the number of metastatic lymph nodes divided by the number of totally resected lymph nodes) has recently emerged as an important prognostic factor in colorectal cancer (CRC). However, the tumor node metastasis (TNM) staging system for colorectal cancer does not consider it as a prognostic parameter. Therefore, we conducted a meta-analysis to evaluate the prognostic role of the LNR in node positive CRC. A systematic search was performed in PubMed, Embase and the Cochrane Library for relevant studies up to November 2015. As a result, a total of 75,838 node positive patients in 33 studies were included in this meta-analysis. Higher LNR was significantly associated with shorter overall survival (OS) (HR = 1.91; 95% CI 1.71-2.14; P = 0.0000) and disease free survival (DFS) (HR = 2.75; 95% CI: 2.14-3.53; P = 0.0000). Subgroup analysis showed similar results. Based on these results, LNR was an independent predictor of survival in colorectal cancer patients and should be considered as a parameter in future oncologic staging systems.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- colorectal cancer; lymph node; lymph node ratio; prognostic role; meta-analysis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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