onr:"swepub:oai:DiVA.org:liu-133020"
Sökning: onr:"swepub:oai:DiVA.org:liu-133020" > Dense breast tissue...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04815naa a2200385 4500 | |
| 001 | oai:DiVA.org:liu-133020 | |
| 003 | SwePub | |
| 008 | 161207s2016 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1330202 URI |
| 024 | 7 | a https://doi.org/10.1080/2162402X.2016.12297232 DOI |
| 040 | a (SwePub)liu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Abrahamsson, Annelieu Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US4 aut0 (Swepub:liu)annab29 |
| 245 | 1 0 | a Dense breast tissue in postmenopausal women is associated with a pro-inflammatory microenvironment in vivo |
| 264 | 1 | b TAYLOR & FRANCIS INC,c 2016 |
| 338 | a print2 rdacarrier | |
| 500 | a Funding Agencies|Swedish Cancer Society [2015/309]; Swedish Research Council [2013-2457]; LiU-Cancer; Research Funds of Linkoping University Hospital | |
| 520 | a Inflammation is one of the hallmarks of carcinogenesis. High mammographic density has been associated with increased risk of breast cancer but the mechanisms behind are poorly understood. We evaluated whether breasts with different mammographic densities exhibited differences in the inflammatory microenvironment.Postmenopausal women attending the mammography-screening program were assessed having extreme dense, n = 20, or entirely fatty breasts (nondense), n = 19, on their regular mammograms. Thereafter, the women were invited for magnetic resonance imaging (MRI), microdialysis for the collection of extracellular molecules in situ and a core tissue biopsy for research purposes. On the MRI, lean tissue fraction (LTF) was calculated for a continuous measurement of breast density. LTF confirmed the selection from the mammograms and gave a continuous measurement of breast density. Microdialysis revealed significantly increased extracellular in vivo levels of IL-6, IL-8, vascular endothelial growth factor, and CCL5 in dense breast tissue as compared with nondense breasts. Moreover, the ratio IL-1Ra/IL-1 was decreased in dense breasts. No differences were found in levels of IL-1, IL-1Ra, CCL2, leptin, adiponectin, or leptin:adiponectin ratio between the two breast tissue types. Significant positive correlations between LTF and the pro-inflammatory cytokines as well as between the cytokines were detected. Stainings of the core biopsies exhibited increased levels of immune cells in dense breast tissue.Our data show that dense breast tissue in postmenopausal women is associated with a pro-inflammatory microenvironment and, if confirmed in a larger cohort, suggests novel targets for prevention therapies for women with dense breast tissue. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 653 | a Cytokines; mammary gland; mammography; microdialysis; MRI | |
| 700 | 1 | a Rzepecka, Annau Region Östergötland, Röntgenkliniken i Linköping4 aut |
| 700 | 1 | a Romu, Thobiasu Linköpings universitet,Medicinsk informatik,Tekniska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV4 aut0 (Swepub:liu)thoro52 |
| 700 | 1 | a Borga, Magnusu Linköpings universitet,Medicinsk informatik,Tekniska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV4 aut0 (Swepub:liu)magbo72 |
| 700 | 1 | a Dahlqvist Leinhard, Olof,d 1978-u Linköpings universitet,Avdelningen för radiologiska vetenskaper,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Radiofysikavdelningen US4 aut0 (Swepub:liu)oloda24 |
| 700 | 1 | a Lundberg, Peteru Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Avdelningen för radiologiska vetenskaper,Medicinska fakulteten,Region Östergötland, Radiofysikavdelningen US4 aut0 (Swepub:liu)petlu11 |
| 700 | 1 | a Kihlberg, Johanu Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Avdelningen för radiologiska vetenskaper,Medicinska fakulteten,Region Östergötland, Röntgenkliniken i Linköping4 aut0 (Swepub:liu)johki53 |
| 700 | 1 | a Dabrosin, Charlottau Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US4 aut0 (Swepub:liu)chada67 |
| 710 | 2 | a Linköpings universitetb Avdelningen för kliniska vetenskaper4 org |
| 773 | 0 | t Oncoimmunologyd : TAYLOR & FRANCIS INCg 5:10q 5:10x 2162-4011x 2162-402X |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-133020 |
| 856 | 4 8 | u https://doi.org/10.1080/2162402X.2016.1229723 |
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