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Efficacy of Self-gu...
Efficacy of Self-guided Internet-Based Cognitive Behavioral Therapy in the Treatment of Depressive Symptoms A Meta-analysis of Individual Participant Data
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- Karyotaki, Eirini (författare)
- Vrije University of Amsterdam, Netherlands
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- Riper, Heleen (författare)
- Vrije University of Amsterdam, Netherlands
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- Twisk, Jos (författare)
- University of Amsterdam, Netherlands
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- Hoogendoorn, Adriaan (författare)
- Geestelijke Gezondheidszorg inGeest inGeest, Netherlands; University of Medical Centre, Netherlands; Vrije University of Amsterdam, Netherlands
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- Kleiboer, Annet (författare)
- Vrije University of Amsterdam, Netherlands
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- Mira, Adriana (författare)
- Jaume University, Spain
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- Mackinnon, Andrew (författare)
- University of Amsterdam, Netherlands; Prince Wales Hospital, Australia
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- Meyer, Bjorn (författare)
- University of Amsterdam, Netherlands; Gaia AG, Germany; IBER Physiopathol Obes and Nutr, Spain
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- Botella, Cristina (författare)
- Jaume University, Spain
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- Littlewood, Elizabeth (författare)
- University of York, England
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- Andersson, Gerhard (författare)
- Karolinska Institutet,Linköpings universitet,Psykologi,Filosofiska fakulteten,Karolinska Institute Disabil Research, Sweden
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- Christensen, Helen (författare)
- University of Amsterdam, Netherlands; Prince Wales Hospital, Australia
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- Klein, Jan P. (författare)
- Luebeck University, Germany
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- Schroeder, Johanna (författare)
- University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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- Breton-Lopez, Juana (författare)
- Jaume University, Spain
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- Scheider, Justine (författare)
- University of Medical Centre Hamburg Eppendorf, Germany; University of Nottingham, England
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- Griffiths, Kathy (författare)
- Australian National University, Australia
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- Farrer, Louise (författare)
- Australian National University, Australia
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- Huibers, Marcus J. H. (författare)
- Vrije Universiteit Amsterdam, Amsterdam, the Netherlands
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- Phillips, Rachel (författare)
- Kings Coll London, England
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- Gilbody, Simon (författare)
- University of York, England
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- Moritz, Steffen (författare)
- University of Medical Centre Hamburg Eppendorf, Germany
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- Berger, Thomas (författare)
- University of Bern, Switzerland
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- Pop, Victor (författare)
- Tilburg University of and Diagnost Centre Eindhoven, Netherlands
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- Spek, Viola (författare)
- Tilburg University of and Diagnost Centre Eindhoven, Netherlands
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- Cuijpers, Pim (författare)
- Vrije Universiteit Amsterdam, Amsterdam, the Netherlands
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(creator_code:org_t)
- AMER MEDICAL ASSOC, 2017
- 2017
- Engelska.
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Ingår i: JAMA psychiatry. - : AMER MEDICAL ASSOC. - 2168-6238 .- 2168-622X. ; 74:4, s. 351-359
- Relaterad länk:
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http://repositori.uj...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- IMPORTANCE Self-guided internet-based cognitive behavioral therapy (iCBT) has the potential to increase access and availability of evidence-based therapy and reduce the cost of depression treatment. OBJECTIVES To estimate the effect of self-guided iCBT in treating adults with depressive symptoms compared with controls and evaluate the moderating effects of treatment outcome and response. DATA SOURCES A total of 13 384 abstracts were retrieved through a systematic literature search in PubMed, Embase, PsycINFO, and Cochrane Library from database inception to January 1, 2016. STUDY SELECTION Randomized clinical trials in which self-guided iCBT was compared with a control (usual care, waiting list, or attention control) in individuals with symptoms of depression. DATA EXTRACTION AND SYNTHESIS Primary authors provided individual participant data from 3876 participants from 13 of 16 eligible studies. Missing data were handled using multiple imputations. Mixed-effects models with participants nested within studies were used to examine treatment outcomes and moderators. MAIN OUTCOMES AND MEASURES Outcomes included the Beck Depression Inventory, Center for Epidemiological Studies-Depression Scale, and 9-item Patient Health Questionnaire scores. Scales were standardized across the pool of the included studies. RESULTS Of the 3876 study participants, the mean (SD) age was 42.0 (11.7) years, 2531 (66.0%) of 3832 were female, 1368 (53.1%) of 2574 completed secondary education, and 2262 (71.9%) of 3146 were employed. Self-guided iCBT was significantly more effective than controls on depressive symptoms severity (beta = -0.21; Hedges g = 0.27) and treatment response (beta = 0.53; odds ratio, 1.95; 95% CI, 1.52-2.50; number needed to treat, 8). Adherence to treatment was associated with lower depressive symptoms (beta = -0.19; P = .001) and greater response to treatment (beta = 0.90; P amp;lt; .001). None of the examined participant and study-level variables moderated treatment outcomes. CONCLUSIONS AND RELEVANCE Self-guided iCBT is effective in treating depressive symptoms. The use of meta-analyses of individual participant data provides substantial evidence for clinical and policy decision making because self-guided iCBT can be considered as an evidence-based first-step approach in treating symptoms of depression. Several limitations of the iCBT should be addressed before it can be disseminated into routine care.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
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Karyotaki, Eirin ...
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Riper, Heleen
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Twisk, Jos
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Hoogendoorn, Adr ...
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Kleiboer, Annet
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Mira, Adriana
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Mackinnon, Andre ...
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Meyer, Bjorn
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Botella, Cristin ...
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Littlewood, Eliz ...
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Andersson, Gerha ...
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Christensen, Hel ...
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Klein, Jan P.
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Schroeder, Johan ...
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Breton-Lopez, Ju ...
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Scheider, Justin ...
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Griffiths, Kathy
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Farrer, Louise
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Huibers, Marcus ...
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Phillips, Rachel
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Gilbody, Simon
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Moritz, Steffen
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Berger, Thomas
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Pop, Victor
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Spek, Viola
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Cuijpers, Pim
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och Klinisk medicin
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JAMA psychiatry
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Linköpings universitet
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Karolinska Institutet