Sökning: onr:"swepub:oai:DiVA.org:liu-139640" >
Biomarker Profiles ...
Biomarker Profiles in Heart Failure Patients With Preserved and Reduced Ejection Fraction
-
- Tromp, Jasper (författare)
- University of Groningen, Netherlands
-
- Khan, Mohsin A. F. (författare)
- University of Groningen, Netherlands; Academic Medical Centre, Netherlands
-
- Klip, IJsbrand T. (författare)
- University of Groningen, Netherlands
-
visa fler...
-
- Meyer, Sven (författare)
- University of Groningen, Netherlands; Carl von Ossietzky University of Oldenburg, Germany
-
- de Boer, Rudolf A. (författare)
- University of Groningen, Netherlands
-
- Jaarsma, Tiny (författare)
- Linköpings universitet,Avdelningen för omvårdnad,Medicinska fakulteten
-
- Hillege, Hans (författare)
- University of Groningen, Netherlands
-
- van Veldhuisen, Dirk J. (författare)
- University of Groningen, Netherlands
-
- van der Meer, Peter (författare)
- University of Groningen, Netherlands
-
- Voors, Adriaan A. (författare)
- University of Groningen, Netherlands
-
visa färre...
-
(creator_code:org_t)
- WILEY, 2017
- 2017
- Engelska.
-
Ingår i: Journal of the American Heart Association. - : WILEY. - 2047-9980. ; 6:4
- Relaterad länk:
-
https://liu.diva-por... (primary) (Raw object)
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background-Biomarkers may help us to unravel differences in the underlying pathophysiology between heart failure (HF) patients with a reduced ejection fraction (HFrEF) and a preserved ejection fraction (HFpEF). Therefore, we compared biomarker profiles to characterize pathophysiological differences between patients with HFrEF and HFpEF. Methods and Results-We retrospectively analyzed 33 biomarkers from different pathophysiological domains (inflammation, oxidative stress, remodeling, cardiac stretch, angiogenesis, arteriosclerosis, and renal function) in 460 HF patients (21% HFpEF, left ventricular ejection fraction amp;gt;= 45%) measured at discharge after hospitalization for acute HF. The association between these markers and the occurrence of all-cause mortality and/or HF-related rehospitalizations at 18 months was compared between patients with HFrEF and HFpEF. Patients were 70.6 +/- 11.4 years old and 37.4% were female. Patients with HFpEF were older, more often female, and had a higher systolic blood pressure. Levels of high-sensitive C-reactive protein were significantly higher in HFpEF, while levels of pro-atrial-type natriuretic peptide and N-terminal pro-brain natriuretic peptide were higher in HFrEF. Linear regression followed by network analyses revealed prominent inflammation and angiogenesis-associated interactions in HFpEF and mainly cardiac stretch-associated interactions in HrEF. The angiogenesis-specific marker, neuropilin and the remodeling-specific marker, osteopontin were predictive for all-cause mortality and/or HF-related rehospitalizations at 18 months in HFpEF, but not in HFrEF (P for interaction amp;lt;0.05). Conclusions-In HFpEF, inflammation and angiogenesis- mediated interactions are predominantly observed, while stretch-mediated interactions are found in HFrEF. The remodeling marker osteopontin and the angiogenesis marker neuropilin predicted outcome in HFpEF, but not in HFrEF.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- biomarker; heart failure; multimarker; pathophysiology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Tromp, Jasper
-
Khan, Mohsin A. ...
-
Klip, IJsbrand T ...
-
Meyer, Sven
-
de Boer, Rudolf ...
-
Jaarsma, Tiny
-
visa fler...
-
Hillege, Hans
-
van Veldhuisen, ...
-
van der Meer, Pe ...
-
Voors, Adriaan A ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Kardiologi
- Artiklar i publikationen
-
Journal of the A ...
- Av lärosätet
-
Linköpings universitet