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HIV/Human herpesvir...
HIV/Human herpesvirus co-infections: Impact on tryptophan-kynurenine pathway and immune reconstitution
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- Hwei Yap, Siew (författare)
- University of Malaya, Malaysia
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- Kamila Abdullah, Noor (författare)
- University of Malaya, Malaysia
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- McStea, Megan (författare)
- University of Malaya, Malaysia
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- Takayama, Kozo (författare)
- Hoshi University, Japan
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- Li Chong, Meng (författare)
- University of Malaya, Malaysia
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- Crisci, Elisa (författare)
- Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten
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- Larsson, Marie (författare)
- Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten
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- Azwa, Iskandar (författare)
- University of Malaya, Malaysia; University of Malaya, Malaysia
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- Kamarulzaman, Adeeba (författare)
- University of Malaya, Malaysia; University of Malaya, Malaysia
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- Hoong Leong, Kok (författare)
- University of Malaya, Malaysia
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- Ling Woo, Yin (författare)
- University of Malaya, Malaysia; University of Malaya, Malaysia
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- Rajasuriar, Reena (författare)
- University of Malaya, Malaysia; University of Malaya, Malaysia; University of Melbourne, Australia
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(creator_code:org_t)
- 2017-10-09
- 2017
- Engelska.
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Ingår i: PLOS ONE. - : PUBLIC LIBRARY SCIENCE. - 1932-6203. ; 12:10
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://journals.plo...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background Co-infections with human herpesvirus (HHV) have been associated with residual chronic inflammation in antiretroviral (ART)-treated human immunodeficiency virus (HIV)-infected individuals. However, the role of HHV in modulating the tryptophan-kynurenine pathway and clinical outcomes in HIV-infected individuals is poorly understood. Thus, we investigated the seroprevalence of four common HHVs among treated HIV-infected participants and their impact on kynurenine/tryptophan (K/T) ratio and long-term CD4 T-cell recovery in HIV/HHV co-infected participants. Method In this cross-sectional study, HIV-infected participants receiving suppressive ART for a minimum of 12 months were recruited from the University Malaya Medical Centre (UMMC), Malaysia. Stored plasma was analyzed for CMV, VZV, HSV-1 and HSV-2 IgG antibody levels, immune activation markers (interleukin-6, interferon-gamma, neopterin and sCD14), kynurenine and tryptophan concentrations. The influence of the number of HHV co-infection and K/T ratio on CD4 T-cell recovery was assessed using multivariate Poisson regression. Results A total of 232 HIV-infected participants were recruited and all participants were seropositive for at least one HHV; 96.1% with CMV, 86.6% with VZV, 70.7% with HSV-1 and 53.9% with HSV-2. K/T ratio had a significant positive correlation with CMV (rho = 0.205, p = 0.002), VZV (rho = 0.173, p = 0.009) and a tendency with HSV-2 (rho = 0.120, p = 0.070), with CMV antibody titer demonstrating the strongest modulating effect on K/T ratio among the four HHVs assessed in SOM analysis. In multivariate analysis, higher K/T ratio (p = 0.03) and increasing number of HHV co-infections (pamp;lt;0.001) were independently associated with poorer CD4 T-cell recovery following 12 months of ART initiation. Conclusion Multiple HHV co-infections are common among ART-treated HIV-infected participants in the developing country setting and associated with persistent immune activation and poorer CD4 T-cell recovery.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Hwei Yap, Siew
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Kamila Abdullah, ...
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McStea, Megan
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Takayama, Kozo
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Li Chong, Meng
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Crisci, Elisa
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visa fler...
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Larsson, Marie
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Azwa, Iskandar
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Kamarulzaman, Ad ...
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Hoong Leong, Kok
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Ling Woo, Yin
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Rajasuriar, Reen ...
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