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Cytokine mapping of...
Cytokine mapping of sera from women with preeclampsia and from women with normal pregnancies
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- Jonsson, Yvonne (författare)
- Linköpings universitet,Klinisk immunologi,Hälsouniversitetet
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- Rubér, Marie (författare)
- Linköpings universitet,Klinisk immunologi,Hälsouniversitetet
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- Matthiesen, Leif (författare)
- Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet
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- Berg, Göran (författare)
- Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet
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- Nieminen, Katri (författare)
- Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet
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- Sharma, Surendra (författare)
- Departments of Pediatrics and Pathology, Brown University and Women and Infants’ Hospital of Rhode Island, Providence, RI, USA
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- Ernerudh, Jan (författare)
- Linköpings universitet,Klinisk immunologi,Hälsouniversitetet
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- Ekerfelt, Christina (författare)
- Linköpings universitet,Klinisk immunologi,Hälsouniversitetet
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(creator_code:org_t)
- Elsevier BV, 2006
- 2006
- Engelska.
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Ingår i: Journal of Reproductive Immunology. - : Elsevier BV. - 0165-0378. ; 70:1-2, s. 83-91
- Relaterad länk:
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http://urn.kb.se/res...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Introduction Preeclampsia is a pregnancy-specific syndrome. The immune system in preeclampsia is changed with an increased innate activity and there is a hypothesis of a shift towards Th1-type immunity. The aim of this study was to determine a spectrum of soluble immunological factors denoting different aspects of immune activation in third trimester sera from women with preeclampsia (N = 15) and compare with levels in sera from normal pregnant women (N = 15). Material and methods IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12 p40, IL-13, IL-15, IL-17, IFN-α, IFN-γ, TNF-α, GM-CSF, MIP-lα, MIP-1β, MCP-1, eotaxin and RANTES were measured in serum using multiplex bead arrays. The levels of soluble CD14 and soluble IL-4 receptor were measured by enzyme-linked immunoassay (ELISA). Results Preeclamptic women had significantly increased levels of circulating IL-6 (p = 0.002), IL-8 (p = 0.003) and soluble IL-4R (p = 0.037), compared to women with normal pregnancies. Conclusion This study supports the hypothesis of increased inflammatory responses in preeclampsia, illustrated by the increased levels of IL-6 and IL-8. The finding of increased levels of soluble IL-4 receptor is an intriguing finding with several interpretations, which may partly support the hypothesis of a Th1 shift in preeclampsia.
Nyckelord
- Cytokines; Serum; Multiple bead array; Preeclampsia
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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