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MYC is downregulate...
MYC is downregulated by a mitochondrial checkpoint mechanism
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- Zhang, Xiaonan (författare)
- Karolinska Institutet,Karolinska Institute, Sweden
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- Mofers, Arjan (författare)
- Linköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten
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- Hydbring, Per (författare)
- Karolinska Institutet,Karolinska Institute, Sweden
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- Hagg Olofsson, Maria (författare)
- Karolinska Institute, Sweden
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- Guo, Jing (författare)
- Karolinska Institutet,Karolinska Institute, Sweden; Duke NUS National University of Singapore Medical Sch, Singapore
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- Linder, Stig (författare)
- Karolinska Institutet,Linköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,Karolinska Institute, Sweden
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- D´arcy, Padraig (författare)
- Karolinska Institutet,Linköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten
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(creator_code:org_t)
- 2017-10-06
- 2017
- Engelska.
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Ingår i: Oncotarget. - : IMPACT JOURNALS LLC. - 1949-2553. ; 8:52, s. 90225-90237
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://www.oncotarg...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The MYC proto-oncogene serves as a rheostat coupling mitogenic signaling with the activation of genes regulating growth, metabolism and mitochondrial biogenesis. Here we describe a novel link between mitochondria and MYC levels. Perturbation of mitochondrial function using a number of conventional and novel inhibitors resulted in the decreased expression of MYC mRNA. This decrease in MYC mRNA occurred concomitantly with an increase in the levels of tumor-suppressive miRNAs such as members of the let-7 family and miR-34a-5p. Knockdown of let-7 family or miR-34a-5p could partially restore MYC levels following mitochondria damage. We also identified let-7-dependent downregulation of the MYC mRNA chaperone, CRD-BP (coding region determinant-binding protein) as an additional control following mitochondria damage. Our data demonstrates the existence of a homeostasis mechanism whereby mitochondrial function controls MYC expression.
Ämnesord
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Nyckelord
- mitochondria; MYC; CRD-BP; let-7/miR-34a; cancer
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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