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On type 1 diabetes ...
On type 1 diabetes mellitus pathogenesis
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- Paschou, Stavroula A (författare)
- Division of Endocrinology and Diabetes, "Aghia Sophia" Hospital, National and Kapodistrian University of Athens - Faculty of Medicine, Athens, Greece
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- Papadopoulou-Marketou, Nektaria (författare)
- Division of Endocrinology and Diabetes, "Aghia Sophia" Hospital, National and Kapodistrian University of Athens - Faculty of Medicine, Athens, Greece
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- Chrousos, George (författare)
- Division of Endocrinology and Diabetes, "Aghia Sophia" Hospital, National and Kapodistrian University of Athens - Faculty of Medicine, Athens, Greece
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- Kanaka-Gantenbein, Christina (författare)
- Division of Endocrinology and Diabetes, "Aghia Sophia" Hospital, National and Kapodistrian University of Athens - Faculty of Medicine, Athens, Greece
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(creator_code:org_t)
- Bioscientifica, 2018
- 2018
- Engelska.
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Ingår i: Endocrine Connections. - : Bioscientifica. - 2049-3614. ; 7:1, s. R38-R46
- Relaterad länk:
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https://doi.org/10.1...
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Type 1 diabetes mellitus (T1DM) results from the autoimmune destruction of β cells of the endocrine pancreas. Pathogenesis of type 1 diabetes mellitus is different from that of type 2 diabetes mellitus, where both insulin resistance and reduced secretion of insulin by the β cells play a synergistic role. We will present genetic, environmental and immunologic factors that destroy β cells of the endocrine pancreas and lead to insulin deficiency. The process of autoimmune destruction takes place in genetically susceptible individuals under the triggering effect of one or more environmental factors and usually progresses over a period of many months to years, during which period patients are asymptomatic and euglycemic, but positive for relevant autoantibodies. Symptomatic hyperglycemia and frank diabetes occurs after a long latency period, which reflects the large percentage of β cells that need to be destroyed before overt diabetes become evident.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- type 1 diabetes
- pathogenesis
- genetics
- autoimmunity
- microbiota
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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