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High expression of ...
High expression of stromal PDGFRß is associated with reduced benefit of tamoxifen in breast cancer
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- Paulsson, Janna (författare)
- Karolinska Institutet,Department of Oncology-Pathology Cancer Center Karolinska, Karolinska Institutet Stockholm, Sweden
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- Rydén, Lisa (författare)
- Lund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Bröstcancerkirurgi,Forskargrupper vid Lunds universitet,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Breast Cancer Surgery,Lund University Research Groups,Division of Surgery, Department of Clinical Sciences Lund UniversityLundSweden; Department of Surgery Skåne University Hospital Lund, Sweden
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- Strell, Carina (författare)
- Karolinska Institutet,Department of Oncology-Pathology Cancer Center Karolinska, Karolinska Institutet Stockholm, Sweden
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- Frings, Oliver (författare)
- Karolinska Institutet,Department of Oncology-Pathology Cancer Center Karolinska, Karolinska Institutet Stockholm, Sweden
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- Tobin, Nicholas P (författare)
- Karolinska Institutet,Department of Oncology-Pathology Cancer Center Karolinska, Karolinska Institutet Stockholm, Sweden
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- Fornander, Tommy (författare)
- Karolinska Institutet,Department of Oncology-Pathology Cancer Center Karolinska, Karolinska Institutet Stockholm, Sweden
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- Bergh, Jonas (författare)
- Karolinska Institutet,Department of Oncology-PathologyCancer Center Karolinska, Karolinska InstitutetStockholmSweden; Radiumhemmet, Karolinska University Hospital Stockholm, Sweden
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- Landberg, Göran (författare)
- University of Gothenburg,Department of Pathology Sahlgrenska Cancer Centre, University of Gothenburg Gothenburg, Sweden
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- Stål, Olle (författare)
- Linköping University,Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US
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- Östman, Arne (författare)
- Karolinska Institutet,Department of Oncology-Pathology Cancer Center Karolinska, Karolinska Institutet Stockholm, Sweden
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(creator_code:org_t)
- 2016-09-14
- 2017
- Engelska.
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Ingår i: The journal of pathology. Clinical research. - : Wiley-Blackwell. - 2056-4538. ; 3:1, s. 38-43
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https://liu.diva-por... (primary) (Raw object)
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https://onlinelibrar...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Cancer-associated fibroblasts (CAFs) regulate tumour growth, metastasis and response to treatment. Recent studies indicate the existence of functionally distinct CAF subsets. Suggested mechanisms whereby CAFs can impact on treatment response include paracrine signalling affecting cancer cell drug sensitivity and effects on tumour drug uptake. PDGFRß is an important regulator of fibroblasts. Experimental studies have linked PDGFRß-positive fibroblasts to metastasis and also to reduced tumour drug uptake. This study has investigated the potential role of PDGFRß-positive fibroblasts in response to adjuvant tamoxifen treatment of breast cancer. Analyses of two breast cancer collections from randomised studies analysing adjuvant tamoxifen treatment in early breast cancer demonstrated significant benefit of tamoxifen in the group with low stromal PDGFRß, which was not observed in the group with high stromal PDGFRß. In general terms these findings provide novel evidence, derived from analyses of randomised clinical studies, of response-predictive capacity of a marker-defined subset of CAFs and, more specifically, identify stromal PDGFRß as a marker related to tamoxifen benefit in early breast cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- PDGFRß; breast cancer; tamoxifen; tumour stroma
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Paulsson, Janna
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Rydén, Lisa
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Strell, Carina
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Frings, Oliver
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Tobin, Nicholas ...
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Fornander, Tommy
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visa fler...
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Bergh, Jonas
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Landberg, Göran
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Stål, Olle
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Östman, Arne
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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The journal of p ...
- Av lärosätet
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Linköpings universitet
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Lunds universitet
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Karolinska Institutet