Sökning: onr:"swepub:oai:DiVA.org:liu-145810" >
Predicting pathogen...
Predicting pathogenicity behavior in Escherichia coli population through a state dependent model and TRS profiling
-
- Bartoszek, Krzysztof (författare)
- Linköpings universitet,Statistik och maskininlärning,Filosofiska fakulteten,Uppsala Univ, Sweden
-
- Majchrzak, Marta (författare)
- Polish Acad Sci, Poland
-
- Sakowski, Sebastian (författare)
- Univ Lodz, Poland
-
visa fler...
-
- Kubiak-Szeligowska, Anna B. (författare)
- Polish Acad Sci, Poland
-
- Kaj, Ingemar, 1957- (författare)
- Uppsala universitet,Analys och sannolikhetsteori,Analysis and Probability,Uppsala Univ, Sweden
-
- Parniewski, Pawel (författare)
- Polish Acad Sci, Poland
-
visa färre...
-
(creator_code:org_t)
- 2018-01-31
- 2018
- Engelska.
-
Ingår i: PloS Computational Biology. - : PUBLIC LIBRARY SCIENCE. - 1553-734X .- 1553-7358. ; 14:1
- Relaterad länk:
-
https://liu.diva-por... (primary) (Raw object)
-
visa fler...
-
https://journals.plo...
-
https://doi.org/10.1...
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- The Binary State Speciation and Extinction (BiSSE) model is a branching process based model that allows the diversification rates to be controlled by a binary trait. We develop a general approach, based on the BiSSE model, for predicting pathogenicity in bacterial populations from microsatellites profiling data. A comprehensive approach for predicting pathogenicity in E. coli populations is proposed using the state-dependent branching process model combined with microsatellites TRS-PCR profiling. Additionally, we have evaluated the possibility of using the BiSSE model for estimating parameters from genetic data. We analyzed a real dataset (from 251 E. coli strains) and confirmed previous biological observations demonstrating a prevalence of some virulence traits in specific bacterial sub-groups. The method may be used to predict pathogenicity of other bacterial taxa.
Ämnesord
- NATURVETENSKAP -- Data- och informationsvetenskap -- Bioinformatik (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Bioinformatics (hsv//eng)
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
- NATURVETENSKAP -- Matematik -- Sannolikhetsteori och statistik (hsv//swe)
- NATURAL SCIENCES -- Mathematics -- Probability Theory and Statistics (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas