Sökning: onr:"swepub:oai:DiVA.org:liu-14629" > Differential inside...
Fältnamn | Indikatorer | Metadata |
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000 | 03584naa a2200469 4500 | |
001 | oai:DiVA.org:liu-14629 | |
003 | SwePub | |
008 | 070913s2004 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-146292 URI |
024 | 7 | a https://doi.org/10.1016/j.yexcr.2004.07.0152 DOI |
040 | a (SwePub)liu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Patcha Brodin, Veronikau Linköpings universitet,Medicinsk mikrobiologi,Hälsouniversitetet4 aut0 (Swepub:liu)verpa92 |
245 | 1 0 | a Differential inside-out activation of β2 integrins by leukotriene B4 and fMLP in human neutrophils |
264 | 1 | b Elsevier BV,c 2004 |
338 | a print2 rdacarrier | |
520 | a We have investigated how LTB4, an endogenous chemoattractant encountered early in the inflammatory process, and fMLP, a bacteria-derived chemotactic peptide emanating from the site of infection, mediate inside-out regulation of the β2-integrin. The role of the two chemoattractants on β2-integrin avidity was investigated by measuring their effect on β2-integrin clustering and surface mobility, whereas their effect on β2-integrin affinity was measured by the expression of a high affinity epitope, a ligand-binding domain on β2-integrins, and by integrin binding to s-ICAM. We find that the two chemoattractants modulate the β2-integrin differently. LTB4 induces an increase in integrin clustering and surface mobility, but only a modest increase in integrin affinity. fMLP evokes a large increase in β2-integrin affinity as well as in clustering and mobility. Lipoxin, which acts as a stop signal for the functions mediated by pro-inflammatory agents, was used as a tool for further examining the inside-out mechanisms. While LTB4-induced integrin clustering and mobility were inhibited by lipoxin, only a minor inhibition of fMLP-induced β2-integrin avidity and no inhibition of integrin affinity were detected. The different modes of the inside-out regulation of β2-integrins suggest that distinct mechanisms are involved in the β2-integrin modulation induced by various chemoattractants. | |
653 | a β2-Integrins | |
653 | a Cell adhesion | |
653 | a Chemotactic factors | |
653 | a Eicosanoids | |
653 | a Inflammation | |
653 | a Leukotriene B4 | |
653 | a Lipoxins | |
653 | a Human Neutrophils | |
653 | a Signal transduction | |
653 | a MEDICINE | |
653 | a MEDICIN | |
700 | 1 | a Wigren, Janeu Linköpings universitet,Medicinsk mikrobiologi,Hälsouniversitetet4 aut0 (Swepub:liu)janwi24 |
700 | 1 | a Winberg, Martin E.4 aut |
700 | 1 | a Rasmusson, Birgittau Linköpings universitet,Medicinsk mikrobiologi,Hälsouniversitetet4 aut0 (Swepub:liu)birra51 |
700 | 1 | a Li, Jianxunu Department of Oral Biology, College of Dentistry, University of Illinois, Chicago, USA4 aut |
700 | 1 | a Särndahl, Evau Linköpings universitet,Cellbiologi,Hälsouniversitetet4 aut0 (Swepub:liu)evasa98 |
710 | 2 | a Linköpings universitetb Medicinsk mikrobiologi4 org |
773 | 0 | t Experimental Cell Researchd : Elsevier BVg 300:2, s. 308-319q 300:2<308-319x 0014-4827x 1090-2422 |
856 | 4 | u http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-9661y Link to Ph.D. Thesis (Veronika Brodin Patcha) |
856 | 4 | u http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-43383y Link to Ph.D. Thesis (Martin Tinnerfelt Winberg) |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-14629 |
856 | 4 8 | u https://doi.org/10.1016/j.yexcr.2004.07.015 |
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