Sökning: onr:"swepub:oai:DiVA.org:liu-14685" >
Cytokine secretion ...
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Lidström Gustafsson, CharlotteÖstergötlands Läns Landsting,Linköpings universitet,Klinisk immunologi,Hälsouniversitetet,Klinisk immunologi och transfusionsmedicin
(författare)
Cytokine secretion patterns of NK cells and macrophages in early human pregnancy decidua and blood : Implications for suppressor macrophages in decidua
- Artikel/kapitelEngelska2003
Förlag, utgivningsår, omfång ...
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Wiley,2003
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-14685
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-14685URI
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https://doi.org/10.1046/j.8755-8920.2003.00112.xDOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Problem: Local immune modulation has been shown to be of considerable importance for the maintenance of successful pregnancy. We have previously reported the secretion of interferon-γ (IFN-γ), interleukin-4 (IL-4) and IL-10 in human decidua from early normal pregnancy. The aim of this study was to investigate the cellular source of cytokine secretion in the decidua, and compare this to secretion patterns in peripheral blood. Method of study: Decidual tissue and peripheral blood was collected from 20 women undergoing surgical abortion during first trimester pregnancy. Monocytes/macrophages and NK cells were enriched by immunomagnetic cell separation and cytokine secretion was detected by enzyme-linked immunosorbent spot-forming cell assay. Results: Decidual and peripheral monocytes/macrophages and NK cells spontaneously secrete IFN-γ, IL-4 and IL-10. The number of IL-10 secreting cells was significantly higher in decidual macrophages compared with decidual non-monocytic cells as well as compared with blood monocytes/macrophages. These differences were not seen for IFN-γ or IL-4. Conclusions: Our results indicate that decidual macrophages subserve important suppressive functions in the pregnant uterus.
Ämnesord och genrebeteckningar
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Decidua
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IFN-γ
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IL-10
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IL-4
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macrophages
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natural killer cells
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pregnancy
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Matthiesen, LeifÖstergötlands Läns Landsting,Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet,Kvinnokliniken i Linköping(Swepub:liu)leima96
(författare)
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Berg, GöranÖstergötlands Läns Landsting,Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet,Kvinnokliniken i Linköping(Swepub:liu)gorbe09
(författare)
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Sharma, SurendraDepartment of Pediatrics & Department of Pathology, Brown University and Women and Infants' Hospital of Rhode Island, Providence, RI, USA
(författare)
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Ernerudh, JanÖstergötlands Läns Landsting,Linköpings universitet,Klinisk immunologi,Hälsouniversitetet,Klinisk immunologi och transfusionsmedicin(Swepub:liu)janer15
(författare)
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Ekerfelt, ChristinaLinköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet(Swepub:liu)chrek55
(författare)
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Linköpings universitetKlinisk immunologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:American Journal of reproductive immunology: Wiley50:6, s. 444-4528755-89201046-74081600-0897
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