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3-Dimensionally ord...
3-Dimensionally ordered macroporous PEDOT ion-exchange resins prepared by vapor phase polymerization for triggered drug delivery: Fabrication and characterization
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- Yasin, M. Naveed (författare)
- Univ Auckland, New Zealand; Univ Auckland, New Zealand
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- Brooke, Robert (författare)
- Linköpings universitet,Institutionen för teknik och naturvetenskap,Tekniska fakulteten,Univ South Australia, Australia
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- Rudd, Sam (författare)
- Univ South Australia, Australia
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- Chan, Andrew (författare)
- Univ Auckland, New Zealand
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- Chen, Wan-Ting (författare)
- Univ Auckland, New Zealand
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- Waterhouse, Geoffrey I. N. (författare)
- Univ Auckland, New Zealand; Univ Auckland, New Zealand
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- Evans, Drew (författare)
- Univ South Australia, Australia
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- Rupenthal, Ilva D. (författare)
- Univ Auckland, New Zealand
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- Svirskis, Darren (författare)
- Univ Auckland, New Zealand
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(creator_code:org_t)
- PERGAMON-ELSEVIER SCIENCE LTD, 2018
- 2018
- Engelska.
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Ingår i: Electrochimica Acta. - : PERGAMON-ELSEVIER SCIENCE LTD. - 0013-4686 .- 1873-3859. ; 269, s. 560-570
- Relaterad länk:
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https://unisa.alma.e...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- This paper reports a simple fabrication strategy towards 3-dimensionally ordered macroporous (3DOM) poly(3,4-ethylenedioxythiophene) (PEDOT) thin films via vapor phase polymerization (VPP) coupled with colloidal crystal templating. PEDOT was synthesized by VPP over a colloidal crystal thin film composed of monodisperse polystyrene colloids functionalized with a Fe(III) tosylate catalyst, after which the polystyrene template was selectively removed. The resulting 3DOM PEDOT films comprised a face-centered cubic array of 280-290 nm spherical macropores in a PEDOT matrix, around 5-6 mu m thick. Cyclic voltammetry (CV) was used to probe electrochemistry and highlighted the merits of the fabrication strategy introduced here; the 3DOM PEDOT films exhibit a 2.9-fold increase in electrochemically available surface area compared to the non-templated PEDOT films. As a demonstration of functionality, ion-exchange of the dopant tosylate for the anionic drug dexamethasone phosphate (dexP(-)) was explored. Loading by passive ion exchange was three-fold higher for 3DOM PEDOT compared with non-templated PEDOT. Notably, CV-driven ion exchange was more efficient to load drug into the polymer than passive ion exchange, and occurred to similar extents for both non-templated PEDOT and 3DOM PEDOT structures. Following loading, minimal dexP(-) release was observed in the absence of an electrical stimulus, while dexP(-) release was triggered upon application of a suitable electrical stimulus. 3DOM PEDOT prepared by VPP thus represents a promising material for use as an ion exchange resin with drug loading achieved subsequent to polymerization and electrically triggered drug release demonstrated. (c) 2018 Elsevier Ltd. All rights reserved.
Ämnesord
- NATURVETENSKAP -- Kemi -- Materialkemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Materials Chemistry (hsv//eng)
Nyckelord
- Conducting polymer; Stimuli-responsive drug delivery; Cyclic voltametric driven ion-exchange; Electro-responsive; Electrically triggered release
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- ref (ämneskategori)
- art (ämneskategori)
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