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Adjustable delivery...
Adjustable delivery of pro-angiogenic FGF-2 by alginate: collagen microspheres
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- Ali, Zaheer (författare)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten
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- Islam, Anik (författare)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten
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- Sherrell, Peter (författare)
- Imperial Coll London, England
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- Le-Moine, Mark (författare)
- Linköpings universitet,Avdelningen för medicinsk teknik,Tekniska fakulteten
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- Lolas, Georgios (författare)
- Univ Athens, Greece
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- Syrigos, Konstantinos (författare)
- Univ Athens, Greece
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- Rafat, Mehrdad (författare)
- Linköpings universitet,Avdelningen för medicinsk teknik,Tekniska fakulteten
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- Jensen, Lasse (författare)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Klinisk farmakologi
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(creator_code:org_t)
- 2018-01-01
- 2018
- Engelska.
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Ingår i: BIOLOGY OPEN. - : COMPANY OF BIOLOGISTS LTD. - 2046-6390. ; 7:3
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://bio.biologis...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Therapeutic induction of blood vessel growth (angiogenesis) in ischemic tissues holds great potential for treatment of myocardial infarction and stroke. Achieving sustained angiogenesis and vascular maturation has, however, been highly challenging. Here, we demonstrate that alginate: collagen hydrogels containing therapeutic, pro-angiogenic FGF-2, and formulated as microspheres, is a promising and clinically relevant vehicle for therapeutic angiogenesis. By titrating the amount of readily dissolvable and degradable collagen with more slowly degradable alginate in the hydrogel mixture, the degradation rates of the biomaterial controlling the release kinetics of embedded proangiogenic FGF-2 can be adjusted. Furthermore, we elaborate a microsphere synthesis protocol allowing accurate control over sphere size, also a critical determinant of degradation/release rate. As expected, alginate: collagen microspheres were completely biocompatible and did not cause any adverse reactions when injected in mice. Importantly, the amount of pro-angiogenic FGF-2 released from such microspheres led to robust induction of angiogenesis in zebrafish embryos similar to that achieved by injecting FGF-2-releasing cells. These findings highlight the use of microspheres constructed from alginate: collagen hydrogels as a promising and clinically relevant delivery system for pro-angiogenic therapy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Hydrogels; Microspheres; Angiogenesis; Vasculature; Zebrafish
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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