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Tumor PIK3CA Genoty...
Tumor PIK3CA Genotype and Prognosis in Early-Stage Breast Cancer: A Pooled Analysis of Individual Patient Data
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- Zardavas, Dimitrios (författare)
- Breast Int Grp, Belgium,Breast International Group
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- te Marvelde, Luc (författare)
- Canc Council, Australia
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- Milne, Roger L. (författare)
- Canc Council, Australia; Univ Melbourne, Australia,University of Melbourne
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- Fumagalli, Debora (författare)
- Breast Int Grp, Belgium,Breast International Group
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- Fountzilas, George (författare)
- Aristotle Univ Thessaloniki, Greece,Aristotle University of Thessaloniki
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- Kotoula, Vassiliki (författare)
- Aristotle Univ Thessaloniki, Greece,Aristotle University of Thessaloniki
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- Razis, Evangelia (författare)
- Hygeia Hosp, Greece,Hygeia Hospital
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- Papaxoinis, George (författare)
- Hippokrateion Hosp, Greece,Hippokration Hospital
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- Joensuu, Heikki (författare)
- Helsinki Univ Hosp, Finland; Univ Helsinki, Finland,Helsinki University Central Hospital,University of Helsinki,Leiden University Medical Centre,Leiden Univ, Netherlands
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- Moynahan, Mary Ellen (författare)
- Mem Sloan Kettering Canc Ctr, NY 10021 USA,Memorial Sloan-Kettering Cancer Center
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- Hennessy, Bryan T. (författare)
- Beaumont Hosp, Ireland; Royal Coll Surg, Ireland,Beaumont Hospital, Dublin
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- Bieche, Ivan (författare)
- Curie Inst, France,Curie Institute, Paris
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- Saal, Lao H. (författare)
- Lund University,Lunds universitet,Translational Oncogenomics,Forskargrupper vid Lunds universitet,Lund University Research Groups,Lund Univ, Sweden
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- Stål, Olle (författare)
- Linköping University,Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US
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- Iacopetta, Barry (författare)
- Univ Western Australia, Australia,University of Western Australia, Crawley
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- Jensen, Jeanette Dupont (författare)
- Univ Southern Denmark, Denmark,University of Southern Denmark
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- OToole, Sandra (författare)
- Garvan Inst Med Res, Australia,Garvan Institute of Medical Research
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- Lopez-Knowles, Elena (författare)
- Garvan Inst Med Res, Australia; Royal Marsden NHS Trust, England; Inst Canc Res, England,Garvan Institute of Medical Research,Institute of Cancer Research London
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- Barbaraeschi, Mattia (författare)
- Santa Chiara Hosp, Italy,Santa Chiara Hospital, Trento
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- Noguchi, Shinzaburo (författare)
- Osaka Univ, Japan,Osaka University
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- Azim, Hatem A. Jr. (författare)
- Amer Univ Beirut, Lebanon,American University of Beirut
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- Lerma, Enrique (författare)
- Univ Autonoma Barcelona, Spain,Autonomous University of Barcelona
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- Bachelot, Thomas (författare)
- Ctr Rech Cancerol Lyon, France,Centre de Recherche en Cancérologie de Lyon
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- Wang, Qing (författare)
- Linköping University,Linköpings universitet
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- Perez Tenorio, Gizeh (författare)
- Linköping University,Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten
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- de Velde, Cornelis J. H. Can (författare)
- Leiden Univ, Netherlands
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- Rea, Daniel W. (författare)
- Univ Birmingham, England,University of Birmingham
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- Sabine, Vicky (författare)
- Univ Guelph, Canada,University of Guelph
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- Bartlett, John M. S. (författare)
- Ontario Inst Canc Res, Canada,Ontario Institute for Cancer Research,University of Paris-Saclay,Gustave Roussy, France; Univ Paris Saclay, France
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- Sotiriou, Christos (författare)
- Univ Libre Bruxelles, Belgium,Université Libre de Bruxelles (ULB)
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- Michiels, Stefan (författare)
- Gustave Roussy, France; Univ Paris Saclay, France
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- Loi, Sherene (författare)
- Univ Melbourne, Australia,University of Melbourne
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(creator_code:org_t)
- AMER SOC CLINICAL ONCOLOGY, 2018
- 2018
- Engelska.
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Ingår i: Journal of Clinical Oncology. - : AMER SOC CLINICAL ONCOLOGY. - 0732-183X .- 1527-7755. ; 36:10, s. 981-
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- PurposePhosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) mutations are frequently observed in primary breast cancer. We evaluated their prognostic relevance by performing a pooled analysis of individual patient data.Patients and MethodsAssociations between PIK3CA status and clinicopathologic characteristics were tested by applying Cox regression models adjusted for age, tumor size, nodes, grade, estrogen receptor (ER) status, human epidermal growth factor receptor 2 (HER2) status, treatment, and study. Invasive disease-free survival (IDFS) was the primary end point; distant disease-free survival (DDFS) and overall survival (OS) were also assessed, overall and by breast cancer subtypes.ResultsData from 10,319 patients from 19 studies were included (median OS follow-up, 6.9 years); 1,787 patients (17%) received chemotherapy, 4,036 (39%) received endocrine monotherapy, 3,583 (35%) received both, and 913 (9%) received none or their treatment was unknown. PIK3CA mutations occurred in 32% of patients, with significant associations with ER positivity, increasing age, lower grade, and smaller size (all P amp;lt; .001). Prevalence of PIK3CA mutations was 18%, 22%, and 37% in the ER-negative/HER2-negative, HER2-positive, and ER-positive/HER2-negative subtypes, respectively. In univariable analysis, PIK3CA mutations were associated with better IDFS (HR, 0.77; 95% CI, 0.71 to 0.84; P amp;lt; .001), with evidence for a stronger effect in the first years of follow-up (0 to 5 years: HR, 0.73; 95% CI, 0.66 to 0.81; P amp;lt; .001; 5 to 10 years: HR, 0.82; 95% CI, 0.68 to 0.99; P = .037); amp;gt; 10 years: (HR, 1.15; 95% CI, 0.84 to 1.58; P = .38; P heterogeneity = .02). In multivariable analysis, PIK3CA genotype remained significant for improved IDFS (P = .043), but not for the DDFS and OS end points.ConclusionIn this large pooled analysis, PIK3CA mutations were significantly associated with a better IDFS, DDFS, and OS, but had a lesser prognostic effect after adjustment for other prognostic factors. (C) 2018 by American Society of Clinical Oncology
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Zardavas, Dimitr ...
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te Marvelde, Luc
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Milne, Roger L.
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Fumagalli, Debor ...
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Fountzilas, Geor ...
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Kotoula, Vassili ...
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visa fler...
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Razis, Evangelia
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Papaxoinis, Geor ...
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Joensuu, Heikki
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Moynahan, Mary E ...
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Hennessy, Bryan ...
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Bieche, Ivan
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Saal, Lao H.
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Stål, Olle
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Iacopetta, Barry
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Jensen, Jeanette ...
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OToole, Sandra
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Lopez-Knowles, E ...
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Barbaraeschi, Ma ...
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Noguchi, Shinzab ...
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Azim, Hatem A. J ...
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Lerma, Enrique
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Bachelot, Thomas
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Wang, Qing
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Perez Tenorio, G ...
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de Velde, Cornel ...
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Rea, Daniel W.
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Sabine, Vicky
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Bartlett, John M ...
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Sotiriou, Christ ...
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Michiels, Stefan
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Loi, Sherene
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Journal of Clini ...
- Av lärosätet
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Linköpings universitet
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Lunds universitet