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Synthesis and Chara...
Synthesis and Characterization of Novel Fluoro-glycosylated Porphyrins that can be Utilized as Theranostic Agents
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- Arja, Katriann (författare)
- Linköpings universitet,Kemi,Tekniska fakulteten
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- Elgland, Mathias (författare)
- Linköpings universitet,Kemi,Tekniska fakulteten
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- Appelqvist, Hanna (författare)
- Linköpings universitet,Kemi,Tekniska fakulteten
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- Konradsson, Peter (författare)
- Linköpings universitet,Kemi,Tekniska fakulteten
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- Lindgren, Mikael (författare)
- Department of Physics, Norwegian University of Science and Technology, NTNU, Trondheim, Norway
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- Nilsson, Peter (författare)
- Linköpings universitet,Kemi,Tekniska fakulteten
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(creator_code:org_t)
- 2018-05-18
- 2018
- Engelska.
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Ingår i: ChemistryOpen. - : Wiley-VCH Verlagsgesellschaft. - 2191-1363. ; 7:7, s. 495-503
- Relaterad länk:
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https://doi.org/10.1...
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https://liu.diva-por... (primary) (Raw object)
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Small molecules with modalities for a variety of imaging techniques as well as therapeutic activity are essential, as such molecules render opportunities to simultaneously conduct diagnosis and targeted therapy, so called theranostics. In this regard, glycoporphyrins have proven useful as theranostic agents towards cancer, as well as noncancerous conditions. Herein, the synthesis and characterization of heterobifunctional glycoconjugated porphyrins with two different sugar moieties, a common monosaccharide at three sites, and a 2-fluoro-2-deoxy glucose (FDG) moiety at the fourth site are presented. The fluoro-glycoconjugated porphyrins exhibit properties for multimodal imaging and photodynamic therapy, as well as specificity towards cancer cells. We foresee that our findings might aid in the chemical design of heterobifunctional glycoconjugated porphyrins that could be utilized as theranostic agents.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
Nyckelord
- cancer; glycoporphyrins; imaging; photodynamic therapy; photosensitizers
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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