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Synthesis and Chara...
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Arja, KatriannLinköpings universitet,Kemi,Tekniska fakulteten
(författare)
Synthesis and Characterization of Novel Fluoro-glycosylated Porphyrins that can be Utilized as Theranostic Agents
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
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2018-05-18
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Wiley-VCH Verlagsgesellschaft,2018
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-150279
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-150279URI
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https://doi.org/10.1002/open.201800020DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Funding Agencies|Swedish Foundation for Strategic Research; Swedish Research Council
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Small molecules with modalities for a variety of imaging techniques as well as therapeutic activity are essential, as such molecules render opportunities to simultaneously conduct diagnosis and targeted therapy, so called theranostics. In this regard, glycoporphyrins have proven useful as theranostic agents towards cancer, as well as noncancerous conditions. Herein, the synthesis and characterization of heterobifunctional glycoconjugated porphyrins with two different sugar moieties, a common monosaccharide at three sites, and a 2-fluoro-2-deoxy glucose (FDG) moiety at the fourth site are presented. The fluoro-glycoconjugated porphyrins exhibit properties for multimodal imaging and photodynamic therapy, as well as specificity towards cancer cells. We foresee that our findings might aid in the chemical design of heterobifunctional glycoconjugated porphyrins that could be utilized as theranostic agents.
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Elgland, MathiasLinköpings universitet,Kemi,Tekniska fakulteten(Swepub:liu)matel79
(författare)
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Appelqvist, HannaLinköpings universitet,Kemi,Tekniska fakulteten(Swepub:liu)hanmi48
(författare)
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Konradsson, PeterLinköpings universitet,Kemi,Tekniska fakulteten(Swepub:liu)petko14
(författare)
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Lindgren, MikaelDepartment of Physics, Norwegian University of Science and Technology, NTNU, Trondheim, Norway
(författare)
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Nilsson, PeterLinköpings universitet,Kemi,Tekniska fakulteten(Swepub:liu)petni61
(författare)
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Linköpings universitetKemi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:ChemistryOpen: Wiley-VCH Verlagsgesellschaft7:7, s. 495-5032191-1363
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