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High-performance, p...
High-performance, polymer-based direct cellular interfaces for electrical stimulation and recording
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- Kim, Seong-Min (author)
- Gwangju Inst Sci and Technol, South Korea
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- Kim, Nara (author)
- Gwangju Inst Sci and Technol, South Korea; Gwangju Inst Sci and Technol, South Korea; Gwangju Inst Sci and Technol, South Korea
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- Kim, Youngseok (author)
- Gwangju Inst Sci and Technol, South Korea; Univ Chicago, IL 60637 USA
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- Baek, Min-Seo (author)
- Gwangju Inst Sci and Technol, South Korea
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- Yoo, Minsu (author)
- Univ Chicago, IL 60637 USA
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- Kim, Dongyoon (author)
- Gwangju Inst Sci and Technol, South Korea
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- Lee, Won-June (author)
- Gwangju Inst Sci and Technol, South Korea
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- Kang, Dong-Hee (author)
- Gwangju Inst Sci and Technol, South Korea
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- Kim, Sohee (author)
- Daegu Gyeongbuk Inst Sci and Technol, South Korea
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- Lee, Kwanghee (author)
- Gwangju Inst Sci and Technol, South Korea; Gwangju Inst Sci and Technol, South Korea; Gwangju Inst Sci and Technol, South Korea
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- Yoon, Myung-Han (author)
- Gwangju Inst Sci and Technol, South Korea
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(creator_code:org_t)
- 2018-04-16
- 2018
- English.
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In: NPG ASIA MATERIALS. - : NATURE PUBLISHING GROUP. - 1884-4049 .- 1884-4057. ; 10, s. 255-265
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Abstract
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- Due to the trade-off between their electrical/electrochemical performance and underwater stability, realizing polymer-based, high-performance direct cellular interfaces for electrical stimulation and recording has been very challenging. Herein, we developed transparent and conductive direct cellular interfaces based on a water-stable, high-performance poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) film via solvent-assisted crystallization. The crystallized PEDOT:PSS on a polyethylene terephthalate (PET) substrate exhibited excellent electrical/electrochemical/optical characteristics, long-term underwater stability without film dissolution/delamination, and good viability for primarily cultured cardiomyocytes and neurons over several weeks. Furthermore, the highly crystallized, nanofibrillar PEDOT:PSS networks enabled dramatically enlarged surface areas and electrochemical activities, which were successfully employed to modulate cardiomyocyte beating via direct electrical stimulation. Finally, the high-performance PEDOT:PSS layer was seamlessly incorporated into transparent microelectrode arrays for efficient, real-time recording of cardiomyocyte action potentials with a high signal fidelity. All these results demonstrate the strong potential of crystallized PEDOT:PSS as a crucial component for a variety of versatile bioelectronic interfaces.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Elektroteknik och elektronik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Electrical Engineering, Electronic Engineering, Information Engineering (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Kim, Seong-Min
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Kim, Nara
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Kim, Youngseok
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Baek, Min-Seo
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Yoo, Minsu
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Kim, Dongyoon
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show more...
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Lee, Won-June
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Kang, Dong-Hee
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Kim, Sohee
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Lee, Kwanghee
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Yoon, Myung-Han
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- About the subject
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Electrical Engin ...
- Articles in the publication
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NPG ASIA MATERIA ...
- By the university
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Linköping University