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A comparison of the...
A comparison of the prognostic value of BNP versus NT-proBNP after hospitalisation for heart failure
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- Linssen, G. C. M. (författare)
- Univ Groningen, Netherlands; Hosp Grp Twente, Netherlands; Hosp Grp Twente, Netherlands
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- Jaarsma, Tiny (författare)
- Linköpings universitet,Avdelningen för omvårdnad,Medicinska fakulteten
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- Hillege, H. L. (författare)
- Univ Groningen, Netherlands; Univ Groningen, Netherlands
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- Voors, A. A. (författare)
- Univ Groningen, Netherlands
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- van Veldhuisen, D. J. (författare)
- Univ Groningen, Netherlands
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(creator_code:org_t)
- 2018-08-07
- 2018
- Engelska.
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Ingår i: Netherlands Heart Journal. - : BOHN STAFLEU VAN LOGHUM BV. - 1568-5888 .- 1876-6250. ; 26:10, s. 486-492
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https://liu.diva-por... (primary) (Raw object)
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https://link.springe...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Aims Concentrations of circulating B-type natriuretic peptides provide important prognostic information in heart failure (HF) patients. We directly compared the prognostic performance of brain natriuretic peptide (BNP) versus N-terminal-proBNP (NT-proBNP) measurements in a large population of HF patients at hospital discharge after an admission for decompensated HF. Methods and results BNP and NT-proBNP were measured in 563 stable HF patients before discharge. All patients were followed for a fixed period of 18 months. The primary endpoint was time to first major event (HF hospitalisation or death). Patients were in NYHA class II (47%) or III/IV (53%) at discharge and the mean age of the patients was 71 +/- 11 years, 217 (39%) females, mean left ventricular ejection fraction was 0.32 +/- 0.14 and 234 (42%) had an ischaemic aetiology of HF. During the study, 236 patients (42%) reached the primary endpoint. Multivariate odds ratios of the primary endpoint for doubling of baseline levels of BNP and NT-proBNP were 1.46 (95% CI 1.19-1.80, p amp;lt; 0.001) and 1.45 (95% CI 1.18-1.78, p amp;lt; 0.001), respectively. The multivariable adjusted areas under the receiver-operating characteristic curve for prediction of the primary endpoint for doubling of BNP and NT-proBNP were 0.69 and 0.68, respectively. Direct comparison of the prognostic value of BNP and NT-proBNP did not reveal significant differences. Conclusions BNP and NT-proBNP at discharge for hospitalisation for HF are powerful, and equally strong and independent predictors of all-cause death and HF rehospitalisation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Heart failure; Biomarkers; B-type natriuretic peptides; BNP; NT-proBNP; Prognosis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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