Sökning: onr:"swepub:oai:DiVA.org:liu-153526" > Striatal dopamine d...
Fältnamn | Indikatorer | Metadata |
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000 | 04851naa a2200529 4500 | |
001 | oai:DiVA.org:liu-153526 | |
003 | SwePub | |
008 | 181220s2018 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1535262 URI |
024 | 7 | a https://doi.org/10.1038/s41398-018-0316-22 DOI |
040 | a (SwePub)liu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Hamilton, Paulu Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten4 aut0 (Swepub:liu)pauha77 |
245 | 1 0 | a Striatal dopamine deficits predict reductions in striatal functional connectivity in major depression: a concurrent C-11-raclopride positron emission tomography and functional magnetic resonance imaging investigation |
264 | c 2018-11-30 | |
264 | 1 | b NATURE PUBLISHING GROUP,c 2018 |
338 | a electronic2 rdacarrier | |
500 | a Funding Agencies|Weston Havens Foundation | |
520 | a Major depressive disorder (MDD) is characterized by the altered integration of reward histories and reduced responding of the striatum. We have posited that this reduced striatal activation in MDD is due to tonically decreased stimulation of striatal dopamine synapses which results in decremented propagation of information along the corticostriatal-pallido-thalamic (CSPT) spiral. In the present investigation, we tested predictions of this formulation by conducting concurrent functional magnetic resonance imaging (fMRI) and C-11-raclopride positron emission tomography (PET) in depressed and control (CTL) participants. We scanned 16 depressed and 14 CTL participants with simultaneous fMRI and C-11-raclopride PET. We estimated raclopride binding potential (BPND), voxel-wise, and compared MDD and CTL samples with respect to BPND in the striatum. Using striatal regions that showed significant between-group BPND differences as seeds, we conducted whole-brain functional connectivity analysis using the fMRI data and identified brain regions in each group in which connectivity with striatal seed regions scaled linearly with BPND from these regions. We observed increased BPND in the ventral striatum, bilaterally, and in the right dorsal striatum in the depressed participants. Further, we found that as BPND increased in both the left ventral striatum and right dorsal striatum in MDD, connectivity with the cortical targets of these regions (default-mode network and salience network, respectively) decreased. Deficits in stimulation of striatal dopamine receptors in MDD could account in part for the failure of transfer of information up the CSPT circuit in the pathophysiology of this disorder. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
700 | 1 | a Sacchet, Matthew D.u Stanford Univ, CA 94305 USA4 aut |
700 | 1 | a Hjornevik, Trineu Oslo Univ Hosp, Norway; Norwegian Med Cyclotron Ctr, Norway; Stanford Univ, CA 94305 USA4 aut |
700 | 1 | a Chin, Frederick T.u Stanford Univ, CA 94305 USA4 aut |
700 | 1 | a Shen, Binu Stanford Univ, CA 94305 USA4 aut |
700 | 1 | a Kämpe, Robinu Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten4 aut0 (Swepub:liu)robka95 |
700 | 1 | a Park, Jun Hyungu Stanford Univ, CA 94305 USA4 aut |
700 | 1 | a Knutson, Brian D.u Stanford Univ, CA USA4 aut |
700 | 1 | a Williams, Leanne M.u Stanford Univ, CA 94305 USA4 aut |
700 | 1 | a Borg, Nicholasu Stanford Univ, CA USA4 aut |
700 | 1 | a Zaharchuk, Gregu Stanford Univ, CA 94305 USA4 aut |
700 | 1 | a Camacho, M. Catalinau Univ Pittsburgh, PA 15260 USA4 aut |
700 | 1 | a Mackey, Seanu Stanford Univ, CA 94305 USA4 aut |
700 | 1 | a Heilig, Markusu Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Region Östergötland, Psykiatriska kliniken4 aut0 (Swepub:liu)marhe41 |
700 | 1 | a Drevets, Wayne C.u Janssen Res and Dev LLC, NJ USA4 aut |
700 | 1 | a Glover, Gary H.u Stanford Univ, CA 94305 USA4 aut |
700 | 1 | a Gambhir, Sanjiv S.u Stanford Univ, CA 94305 USA4 aut |
700 | 1 | a Gotlib, Ian H.u Stanford Univ, CA USA4 aut |
710 | 2 | a Linköpings universitetb Centrum för social och affektiv neurovetenskap4 org |
773 | 0 | t Translational Psychiatryd : NATURE PUBLISHING GROUPg 8q 8x 2158-3188 |
856 | 4 | u https://liu.diva-portal.org/smash/get/diva2:1273243/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://www.nature.com/articles/s41398-018-0316-2.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-153526 |
856 | 4 8 | u https://doi.org/10.1038/s41398-018-0316-2 |
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