Sökning: onr:"swepub:oai:DiVA.org:liu-153678" >
MYC Protein Interac...
MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis
-
- Kalkat, Manpreet (författare)
- Univ Toronto, Canada; Univ Hlth Network, Canada
-
- Resetca, Diana (författare)
- Univ Toronto, Canada; Univ Hlth Network, Canada
-
- Lourenco, Corey (författare)
- Univ Toronto, Canada; Univ Hlth Network, Canada
-
visa fler...
-
- Chan, Pak-Kei (författare)
- Univ Hlth Network, Canada
-
- Wei, Yong (författare)
- Univ Hlth Network, Canada; Struct Genom Consortium, Canada
-
- Shiah, Yu-Jia (författare)
- Ontario Inst Canc Res, Canada
-
- Vitkin, Natasha (författare)
- Univ Hlth Network, Canada
-
- Tong, Yufeng (författare)
- Struct Genom Consortium, Canada; Univ Toronto, Canada
-
- Sunnerhagen, Maria (författare)
- Linköpings universitet,Kemi,Tekniska fakulteten
-
- Done, Susan J. (författare)
- Univ Toronto, Canada; Univ Hlth Network, Canada
-
- Boutros, Paul C. (författare)
- Univ Toronto, Canada; Ontario Inst Canc Res, Canada
-
- Raught, Brian (författare)
- Univ Toronto, Canada; Univ Hlth Network, Canada
-
- Penn, Linda Z. (författare)
- Univ Toronto, Canada; Univ Hlth Network, Canada
-
visa färre...
-
(creator_code:org_t)
- CELL PRESS, 2018
- 2018
- Engelska.
-
Ingår i: Molecular Cell. - : CELL PRESS. - 1097-2765 .- 1097-4164. ; 72:5, s. 836-
- Relaterad länk:
-
http://www.cell.com/...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Transforming members of the MYC family (MYC, MYCL1, and MYCN) encode transcription factors containing six highly conserved regions, termed MYC homology boxes (MBs). By conducting proteomic profiling of the MB interactomes, we demonstrate that half of the MYC interactors require one or more MBs for binding. Comprehensive phenotypic analyses reveal that two MBs, MBO and MBII, are universally required for transformation. MBII mediates interactions with acetyltransferase-containing complexes, enabling histone acetylation, and is essential for MYC-dependent tumor initiation. By contrast, MBO mediates interactions with transcription elongation factors via direct binding to the general transcription factor TFIIF. MBO is dispensable for tumor initiation but is a major accelerator of tumor growth. Notably, the full transforming activity of MYC can be restored by co-expression of the non-transforming MBO and MBII deletion proteins, indicating that these two regions confer separate molecular functions, both of which are required for oncogenic MYC activity.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Kalkat, Manpreet
-
Resetca, Diana
-
Lourenco, Corey
-
Chan, Pak-Kei
-
Wei, Yong
-
Shiah, Yu-Jia
-
visa fler...
-
Vitkin, Natasha
-
Tong, Yufeng
-
Sunnerhagen, Mar ...
-
Done, Susan J.
-
Boutros, Paul C.
-
Raught, Brian
-
Penn, Linda Z.
-
visa färre...
- Om ämnet
-
- NATURVETENSKAP
-
NATURVETENSKAP
-
och Biologi
-
och Biokemi och mole ...
- Artiklar i publikationen
-
Molecular Cell
- Av lärosätet
-
Linköpings universitet