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Characterization of...
Characterization of Clinically Relevant Strains of Extended-Spectrum beta-Lactamase-Producing Klebsiella pneumoniae Occurring in Environmental Sources in a Rural Area of China by Using Whole-Genome Sequencing
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- Chi, Xiaohui (författare)
- Shandong Univ, Peoples R China
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- Berglund, Björn (författare)
- Linköpings universitet,Medicinska fakulteten,Avdelningen för mikrobiologi, infektion och inflammation,Zhejiang Univ, Peoples R China
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- Zou, Huiyun (författare)
- Shandong Univ, Peoples R China
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- Zheng, Beiwen (författare)
- Zhejiang Univ, Peoples R China
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- Börjesson, Stefan (författare)
- Linköpings universitet,Medicinska fakulteten,Avdelningen för mikrobiologi, infektion och inflammation,Natl Vet Inst, Sweden
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- Ji, Xiang (författare)
- Shandong Univ, Peoples R China
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- Ottoson, Jakob (författare)
- Natl Food Agcy, Sweden
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- Lundborg, Cecilia Stalsby (författare)
- Karolinska Inst, Sweden
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- Li, Xuewen (författare)
- Shandong Univ, Peoples R China
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- Nilsson, Lennart E (författare)
- Linköpings universitet,Medicinska fakulteten,Avdelningen för mikrobiologi, infektion och inflammation
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(creator_code:org_t)
- 2019-02-12
- 2019
- Engelska.
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Ingår i: Frontiers in Microbiology. - : Frontiers Media S.A.. - 1664-302X. ; 10
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://www.frontier...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Klebsiella pneumoniae is a gram-negative, opportunistic pathogen, and a common cause of healthcare-associated infections such as pneumonia, septicemia, and urinary tract infection. The purpose of this study was to survey the occurrence of and characterize K. pneumoniae in different environmental sources in a rural area of Shandong province, China. Two hundred and thirty-one samples from different environmental sources in 12 villages were screened for extended-spectrum beta-lactamase-(ESBL)-producing K. pneumoniae, and 14 (6%) samples were positive. All isolates were multidrug-resistant and a few of them belonged to clinically relevant strains which are known to cause hospital outbreaks worldwide. Serotypes, virulence genes, serum survival, and phagocytosis survival were analyzed and the results showed the presence of virulence factors associated with highly virulent clones and a high degree of phagocytosis survivability, indicating the potential virulence of these isolates. These results emphasize the need for further studies designed to elucidate the role of the environment in transmission and dissemination of ESBL-producing K. pneumoniae and the potential risk posed to human and environmental health.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- Klebsiella pneumoniae; extended-spectrum beta-lactamase; environment; feces; water; multilocus sequence typing; pulsed-field gel electrophoresis; whole-genome sequencing
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Chi, Xiaohui
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Berglund, Björn
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Zou, Huiyun
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Zheng, Beiwen
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Börjesson, Stefa ...
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Ji, Xiang
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visa fler...
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Ottoson, Jakob
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Lundborg, Cecili ...
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Li, Xuewen
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Nilsson, Lennart ...
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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Frontiers in Mic ...
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Linköpings universitet