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Proteinase-3 and my...
Proteinase-3 and myeloperoxidase serotype in relation to demographic factors and geographic distribution in anti-neutrophil cytoplasmic antibody-associated glomerulonephritis
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- Weiner, Maria (författare)
- Linköping University,Linköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,Region Östergötland, Njurmedicinska kliniken US
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- Bjorneklett, Rune (författare)
- Univ Bergen, Norway; Haukeland Hosp, Norway,University of Bergen,Haukeland University Hospital
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- Hruskova, Zdenka (författare)
- Charles Univ Prague, Czech Republic; Gen Univ Hosp, Czech Republic,Charles University in Prague,General University Hospital in Prague
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- Mackinnon, Bruce (författare)
- Queen Elizabeth Univ Hosp, Scotland,Queen Elizabeth University Hospital
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- Poulton, Caroline J. (författare)
- Univ N Carolina, NC 27515 USA; UNC Kidney Ctr, NC USA,University of North Carolina
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- Sindelar, Leo (författare)
- Linköping University,Linköpings universitet,Institutionen för medicin och hälsa,Medicinska fakulteten,Region Östergötland, Njurmedicinska kliniken US,Queen Elizabeth Univ Hosp, Scotland,Queen Elizabeth University Hospital
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- Mohammad, Aladdin J. (författare)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,University of Cambridge,Lund Univ, Sweden; Univ Cambridge, England
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- Eriksson, Per (författare)
- Linköping University,Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland
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- Gesualdo, Loreto (författare)
- Univ Bari, Italy,University of Bari Aldo Moro
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- Geetha, Duvuru (författare)
- Johns Hopkins Univ, MD USA,Johns Hopkins University
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- Crnogorac, Matija (författare)
- Dubrava Univ Hosp, Croatia,Dubrava University Hospital
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- Jayne, David (författare)
- Univ Cambridge, England,University of Cambridge
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- Hogan, Susan L. (författare)
- Univ N Carolina, NC 27515 USA; UNC Kidney Ctr, NC USA,University of North Carolina
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- Geddes, Colin (författare)
- Queen Elizabeth Univ Hosp, Scotland,Queen Elizabeth University Hospital
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- Tesar, Vladimir (författare)
- Charles Univ Prague, Czech Republic; Gen Univ Hosp, Czech Republic,General University Hospital in Prague,Charles University in Prague
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- Aasarod, Knut (författare)
- St Olavs Univ Hosp, Norway; Norwegian Univ Sci and Technol, Norway,Norwegian University of Science and Technology,St. Olav’s University Hospital
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- Segelmark, Mårten (författare)
- Linköping University,Linköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,Region Östergötland, Njurmedicinska kliniken US
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(creator_code:org_t)
- 2018-04-30
- 2019
- Engelska.
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Ingår i: Nephrology, Dialysis and Transplantation. - : OXFORD UNIV PRESS. - 0931-0509 .- 1460-2385. ; 34:2, s. 301-308
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://europepmc.or...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Background. In anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis, antigen specificity varies between myeloperoxidase (MPO) and proteinase 3 (PR3). This has been reported to vary in relation to age, gender, geography and extrarenal manifestations. However, studies are difficult to compare as criteria for inclusion vary. The aim of this study was to investigate the relationship between ANCA serotype, latitude, ultraviolet (UV) radiation levels, age, gender and renal function at diagnosis in a large study with uniform inclusion criteria. Methods. Patients with biopsy-proven ANCA-associated glomerulonephritis were identified from regional or nationwide registries in 14 centres in Norway, Sweden, the UK, the Czech Republic, Croatia, Italy and the USA during the period 2000-13. UV radiation levels for 2000-13 in Europe were obtained from the Swedish Meteorological and Hydrological Institute. Results. A total of 1408 patients (45.2% PR3-ANCA) were included in the study. In univariable analysis, PR3-ANCA was significantly associated with male gender {odds ratio [OR] 2.12 [95% confidence interval (CI) 1.71-2.62]}, younger age [OR per year 0.97 (95% CI 0.96-0.98)] and higher glomerular filtration rate [OR per mL/min 1.01 (95% CI 1.01-1.02); Pamp;lt;0.001] at diagnosis but not with latitude or UV radiation. In multivariable logistic regression analysis, latitude and UV radiation also became significant, with higher odds for PR3-ANCA positivity at northern latitudes/lower UV radiation levels. However, the latitudinal difference in MPO: PR3 ratio is smaller than differences previously reported concerning microscopic polyangiitis and granulomatosis with polyangiitis. Conclusions. The ratio between PR3-ANCA and MPO-ANCA varies in glomerulonephritis with respect to age, gender, renal function and geographic latitude/UV radiation levels.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- ANCA-associated vasculitis; glomerulonephritis; latitude; MPO-ANCA; PR3-ANCA
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Weiner, Maria
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Bjorneklett, Run ...
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Hruskova, Zdenka
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Mackinnon, Bruce
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Poulton, Carolin ...
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Sindelar, Leo
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visa fler...
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Mohammad, Aladdi ...
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Eriksson, Per
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Gesualdo, Loreto
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Geetha, Duvuru
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Crnogorac, Matij ...
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Jayne, David
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Hogan, Susan L.
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Geddes, Colin
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Tesar, Vladimir
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Aasarod, Knut
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Segelmark, Mårte ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Urologi och njur ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
- Artiklar i publikationen
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Nephrology, Dial ...
- Av lärosätet
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Linköpings universitet
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Lunds universitet