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Parasympathetic Rei...
Parasympathetic Reinnervation Accompanied By Improved Post-Exercise Heart Rate Recovery and Quality of Life in Heart Transplant Recipients
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- Imamura, T. (författare)
- Department of Therapeutic Strategy for Heart Failure, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
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- Kinugawa, K. (författare)
- Department of Therapeutic Strategy for Heart Failure, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
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- Inaba, T. (författare)
- Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
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- Maki, H. (författare)
- Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
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- Hatano, M. (författare)
- Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
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- Kinoshita, O. (författare)
- Department of Cardiac Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
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- Nawata, K. (författare)
- Department of Cardiac Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
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- Ono, M. (författare)
- Department of Cardiac Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
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(creator_code:org_t)
- Elsevier, 2015
- 2015
- Engelska.
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Ingår i: The Journal of Heart and Lung Transplantation. - : Elsevier. - 1053-2498 .- 1557-3117. ; 34:4
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Purpose: Although sympathetic reinnervation is accompanied by the improvement of exercise tolerability during several years after heart trans-plantation (HTx), little is known about parasympathetic reinnervation and its clinical impact.Methods: We enrolled 21 recipients (40 ± 16 years, 71% male) who had received successive cardiopulmonary exercise testing at 6 months, 1, and 2 years after HTx. They also received heart rate (HR) variability analy-ses at post-HTx 6 months, and Minnesota Living with Heart failure (HF) Questionnaire at post-HTx 6 months and 2 years.Results: Exercise parameters such as peak oxygen consumption or maximum load remained unchanged, whereas recovery parameters including HR recov-ery during 2 minutes and the delay of peak HR, both influened by parasym-pathetic activity, improved significantly during post-HTx 2 years (p<0.05 for both). Among 12 recipients who had also received HR variability analyses at 6 months after HTx, high frequency power, representing parasympathetic activity, was significantly associated with 2 recovery parameters (p<0.05 for all). Recipients with improved recovery parameters enjoyed a better HF-specific quality of life that was demonstrated by improved Minnesota Living with HF Questionnaire at post-HTx 2 years.Conclusion: Parasympathetic reinnervation emerges along with improved post-exercise recovery of HR and quality of life during post-HTx 2 years.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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