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Impact of age on th...
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Collet, Jean-PhilippeSorbonne Université Paris 6, ACTION Study Group, Hôpital Pitié-Salpêtrière (AP-HP), Paris, France
(författare)
Impact of age on the effect of pre-hospital P2Y12 receptor inhibition in primary percutaneous coronary intervention for ST-segment elevation myocardial infarction : the ATLANTIC-Elderly analysis
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
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Toulouse, France :Europa Digital & Publishing,2018
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LIBRIS-ID:oai:DiVA.org:liu-155885
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-155885URI
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https://doi.org/10.4244/EIJ-D-18-00182DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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AIMS: The aim of the study was to examine the main results of the ATLANTIC trial in patients with ST-elevation myocardial infarction (STEMI), randomised to pre- versus in-hospital ticagrelor, according to age.METHODS AND RESULTS: Patients were evaluated by age class (<75 vs. ≥75 years) for demographics, prior cardiovascular history, risk factors, management, and outcomes. Elderly patients (≥75 years; 304/1,862) were more likely to be women, diabetic, lean, with a prior history of myocardial infarction and CABG, and with comorbidities (p<0.01 for all). Elderly patients presented more frequently with acute heart failure and less frequently had thromboaspiration, a stent implanted (p<0.01) and an aggressive antithrombotic regimen. Elderly patients had lower rates of pre- and post-PCI ≥70% ST-segment elevation resolution (43.9% vs. 51.6%; p=0.035), of pre- and post-PCI TIMI 3 flow (17.1% vs. 27.5%, p=0.0002), and a higher rate of the composite of death/MI/stroke/urgent revascularisation (9.9% vs. 2.9%; OR 3.67, 95% CI [2.27; 5.93], p<0.0001) and mortality (8.5% vs. 1.5%; OR 6.45, 95% CI [2.75; 15.11], p<0.0001). There was a non-significant trend towards more frequent major bleedings among elderly patients (TIMI major 2.3% vs. 1.1%; OR 2.13, 95% CI [0.88; 5.18], p=0.095). There was no significant interaction between time of ticagrelor administration (pre-hospital versus in-lab) and class of age for all outcomes.CONCLUSIONS: Elderly patients, who represented one sixth of the patients randomised in the ATLANTIC trial, had less successful mechanical reperfusion and a sixfold increase in mortality at 30 days, probably due to comorbidities and possible undertreatment. The effect of early ticagrelor was consistent irrespective of age.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Kerneis, MathieuSorbonne Université Paris 6, ACTION Study Group, Hôpital Pitié-Salpêtrière (AP-HP), Paris, France
(författare)
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Lattuca, BenoitDepartment of Cardiology, CHU Caremeau, Université de Montpellier, ACTION Study Group, Nimes, France
(författare)
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Yan, YanSorbonne Université Paris 6, ACTION Study Group, Hôpital Pitié-Salpêtrière (AP-HP), Paris, France
(författare)
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Cayla, GuillaumeDepartment of Cardiology, CHU Caremeau, Université de Montpellier, ACTION Study Group, Nimes, France
(författare)
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Silvain, JohanneSorbonne Université Paris 6, ACTION Study Group, Hôpital Pitié-Salpêtrière (AP-HP), Paris, France
(författare)
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Lapostolle, FrédéricSAMU 93 Hôpital Avicenne, Bobigny, France
(författare)
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Ecollan, PatrickService Médical d’Urgence, Brigade de Sapeurs-Pompiers de Paris, Paris, France
(författare)
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Diallo, AbdourahmaneACTION Study Group, Unité de Recherche Clinique, Hôpital Lariboisière, Paris, France
(författare)
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Vicaut, EricACTION Study Group, Unité de Recherche Clinique, Hôpital Lariboisière, Paris, France
(författare)
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Hamm, Christian WKerckhoff Klinik, Bad Nauheim, Universitätsklinikum Gießen, Giessen, Germany
(författare)
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Van 't Hof, Arnoud WDepartment of Cardiology, Isala Clinics, Zwolle, the Netherlands
(författare)
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Montalescot, GillesSorbonne Université Paris 6, ACTION Study Group, Hôpital Pitié-Salpêtrière (AP-HP), Paris, France
(författare)
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Janzon, Magnus,1961-Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)magja75
(bidragsgivare)
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Sorbonne Université Paris 6, ACTION Study Group, Hôpital Pitié-Salpêtrière (AP-HP), Paris, FranceDepartment of Cardiology, CHU Caremeau, Université de Montpellier, ACTION Study Group, Nimes, France
(creator_code:org_t)
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Ingår i:EuroInterventionToulouse, France : Europa Digital & Publishing14:7, s. 789-7971774-024X1969-6213
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Kerneis, Mathieu
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Yan, Yan
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Silvain, Johanne
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Lapostolle, Fréd ...
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