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Survival benefit of...
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Kotti, AngelikiLinköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Institutionen för medicin och hälsa,Region Östergötland, Röntgenkliniken i Linköping
(författare)
Survival benefit of statins in older patients with rectal cancer : A Swedish population-based cohort study
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
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Elsevier,2019
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Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-157046
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-157046URI
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https://doi.org/10.1016/j.jgo.2019.01.011DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Funding agencies: Swedish Cancer SocietySwedish Cancer Society; Foundation of Oncological Clinical Research in Linkoping; Swedish Research CouncilSwedish Research Council; Health Research Council in the Southeast of Sweden
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ObjectivesIncreasing evidence suggests that statins may have antitumor effects but their rolein rectal cancer appears inconclusive. The aim of this study was to investigate whether statins may have an impact on survival of older and younger patients with rectal cancer.Materials and MethodsThis study included 238 patients ≥70 years and 227 patients <70 years old, from the Southeast Health Care Region of Sweden, who were diagnosed with rectal adenocarcinoma between 2004 and 2013.ResultsIn the older group (n = 238), statin use at the time of diagnosis was related to better cancer-specific survival (CSS) and overall survival (OS), compared to non-use (CSS: Hazard Ratio (HR), 0.37; 95% CI, 0.19–0.72; P = .003; OS: HR, 0.62; 95% CI, 0.39–0.96; P = .032). In the older group with stages I-III disease (n = 199), statin use was associated with better disease-free survival (DFS) compared to non use (HR, 0.18; 95% CI, 0.06–0.59; P = .005). The improvement of CSS, OS and DFS remained significant after adjusting for potential confounders. In the older group with stage III disease, statin users had better CSS and DFS compared to non-users (log rank P = .043; log-rank P = .028, respectively). In the older group with short course radiotherapy, statin use was related to better CSS (log-rank P = .032). No such association was present in the younger group.ConclusionStatin use was related to improved survival in older patients with rectal cancer.This observation is important given the low cost and safety of statins as a drug.
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Holmqvist, Annica,1974-Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US(Swepub:liu)annkn86
(författare)
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Albertsson, MariaLinköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US(Swepub:liu)maral98
(författare)
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Sun, Xiao-FengLinköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US(Swepub:liu)xiasu45
(författare)
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Linköpings universitetAvdelningen för kliniska vetenskaper
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Geriatric Oncology: Elsevier10:5, s. 690-6971879-40681879-4076
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