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The added value of ...
The added value of health-related quality of life as a prognostic indicator of overall survival and progression-free survival in glioma patients: a meta-analysis based on individual patient data from randomised controlled trials
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- Coomans, Marijke (författare)
- Leiden Univ, Netherlands
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- Dirven, Linda (författare)
- Leiden Univ, Netherlands; Haaglanden Med Ctr, Netherlands
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- Aaronson, Neil K. (författare)
- Netherlands Canc Inst, Netherlands
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- Baumert, Brigitta G. (författare)
- Univ Hosp Bonn, Germany; Maastricht Univ, Netherlands; Maastricht Univ, Netherlands
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- van den Bent, Martin (författare)
- Erasmus MC Canc Inst, Netherlands
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- Bottomley, Andrew (författare)
- European Org Res Treatment Canc, Belgium
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- Brandes, Alba A. (författare)
- Azienda USL IRCCS Inst Neurol Sci, Italy
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- Chinot, Olivier (författare)
- Aix Marseille Univ, France
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- Coens, Corneel (författare)
- European Org Res and Treatment Canc Headquarters, Belgium
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- Gorlia, Thierry (författare)
- Univ Bonn, Germany; Univ Bonn, Germany
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- Herrlinger, Ulrich (författare)
- Grp Hop Pitie Salpetriere, France
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- Keime-Guibert, Florence (författare)
- Groupe Hôpital Pitié-Salpetrière, Paris, France
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- Malmström, Annika, 1957- (författare)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Region Östergötland, Närvårdskliniken
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- Martinelli, Francesca (författare)
- Northwestern Univ, IL 60611 USA
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- Stupp, Roger (författare)
- Azienda Osped San Giovanni Addolorata, Italy
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- Talacchi, Andrea (författare)
- Univ Hosp, Switzerland; Univ Zurich, Switzerland
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- Weller, Michael (författare)
- Univ Hosp Heidelberg, Germany; German Consortium Translat Canc Res DKTK, Germany
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- Wick, Wolfgang (författare)
- Univ Amsterdam, Netherlands
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- Reijneveld, Jaap C. (författare)
- Leiden Univ, Netherlands; Haaglanden Med Ctr, Netherlands
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- Taphoorn, Martin J. B. (författare)
- Leiden University Medical Center, Leiden, Netherlands; Haaglanden Medical Center, Den Haag, Netherlands
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(creator_code:org_t)
- ELSEVIER SCI LTD, 2019
- 2019
- Engelska.
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Ingår i: European Journal of Cancer. - : ELSEVIER SCI LTD. - 0959-8049 .- 1879-0852. ; 116, s. 190-198
- Relaterad länk:
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https://www.zora.uzh...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective: Prognostic value of health-related quality of life (HRQoL) data may be important to inform patients in clinical practice and to guide clinical decision-making. Our study investigated the added prognostic value of HRQoL for overall survival (OS) and progression-free survival (PFS) in a large heterogeneous sample of glioma patients, besides known prognostic factors. Methods: We included individual baseline data from previously published randomised controlled trials (RCTs) in glioma patients in which HRQoL was assessed through the European Organisation for Research and Treatment of Cancer QLQ-C30 and QLQ-BN20 questionnaires. Multivariable Cox regression models (stratified for newly diagnosed versus recurrent disease) were constructed, first with clinical variables (age, sex, tumour type, performance status, allocated treatment and extent of resection) only and subsequently with HRQoL variables added, separately for OS and PFS. The added prognostic value of HRQoL was calculated using C-indices. Results: Baseline HRQoL and clinical data from 15 RCTs were included, comprising 5217 patients. In the model including both clinical and HRQoL variables, better cognitive and role functioning and less motor dysfunction were independently associated with longer OS, whereas better role and cognitive functioning, less nausea and vomiting and more appetite loss were independently associated with prolonged PFS. However, C-indices indicated only a small prognostic improvement of the models for OS and PFS when adding HRQoL to the clinical prognostic variables (+1.1% for OS and +.7% for PFS). Conclusion: Our findings demonstrate that several baseline HRQoL variables are independently prognostic for OS and PFS, yet the added value of HRQoL to the known clinical prognostic variables was small. (C) 2019 Elsevier Ltd. All rights reserved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- Glioma; Health-related quality of life (HRQoL); Prognostic factor; Brain tumour; Survival
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Coomans, Marijke
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Dirven, Linda
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Aaronson, Neil K ...
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Baumert, Brigitt ...
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van den Bent, Ma ...
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Bottomley, Andre ...
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visa fler...
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Brandes, Alba A.
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Chinot, Olivier
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Coens, Corneel
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Gorlia, Thierry
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Herrlinger, Ulri ...
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Keime-Guibert, F ...
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Malmström, Annik ...
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Martinelli, Fran ...
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Stupp, Roger
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Talacchi, Andrea
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Weller, Michael
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Wick, Wolfgang
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Reijneveld, Jaap ...
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Taphoorn, Martin ...
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- MEDICIN OCH HÄLSOVETENSKAP
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och Klinisk medicin
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och Urologi och njur ...
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European Journal ...
- Av lärosätet
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Linköpings universitet