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Increased circulati...
Increased circulating paternal antigen-specific IFN-γ- and IL-4-secreting cells during pregnancy in allergic and non-allergic women
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- Persson, Marie (författare)
- Linköpings universitet,Klinisk immunologi,Hälsouniversitetet
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- Ekerfelt, Christina (författare)
- Linköpings universitet,Klinisk immunologi,Hälsouniversitetet
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- Ernerudh, Jan (författare)
- Linköpings universitet,Klinisk immunologi,Hälsouniversitetet
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- Matthiesen, Leif (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Obstetrik och gynekologi,Kvinnokliniken i Linköping,Hälsouniversitetet
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- Jenmalm, Maria (författare)
- Linköpings universitet,Pediatrik,Hälsouniversitetet
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- Jonsson, Yvonne (författare)
- Linköpings universitet,Klinisk immunologi,Hälsouniversitetet
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- Sandberg, Martina (författare)
- Linköpings universitet,Pediatrik,Hälsouniversitetet
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- Berg, Göran (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Obstetrik och gynekologi,Kvinnokliniken i Linköping,Hälsouniversitetet
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(creator_code:org_t)
- Elsevier BV, 2008
- 2008
- Engelska.
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Ingår i: Journal of Reproductive Immunology. - : Elsevier BV. - 0165-0378 .- 1872-7603. ; 79:1, s. 70-78
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https://liu.diva-por... (primary) (Raw object)
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http://liu.diva-port...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- INTRODUCTION: Allergic women have been reported to give birth to more children than non-allergic women, speculatively explained by the former's predisposition for Th2 polarization, possibly favoring pregnancy.AIM: The aim of this study was to test the hypothesis that allergy is associated with more Th2-deviated responses to paternal antigens throughout pregnancy.METHODS: Blood samples were collected on six occasions during pregnancy and two occasions postpartum (pp). Of the 86 women initially included, 54 women had a normal pregnancy and completed the sampling procedures. Eleven women fulfilled the strict criteria for allergy (allergic symptoms and circulating IgE antibodies to inhalant allergens) and 23 were strictly non-allergic (non-sensitized without symptoms). The numbers of blood mononuclear cells secreting IFN-gamma and IL-4, spontaneously and in response to paternal alloantigens, were compared between the groups.RESULTS: The numbers of spontaneously as well as paternal antigen-induced IFN-gamma- and IL-4-secreting cells were similar in allergic and non-allergic pregnant women on all occasions. A similar increase in the numbers of both IFN-gamma- and IL-4-secreting cells were found in allergic and non-allergic women during pregnancy, both regarding spontaneous and paternal antigen-induced secretion.CONCLUSIONS: This study does not support the hypothesis of a more pronounced Th2-deviation to paternal antigens in allergic pregnant women compared with non-allergic pregnant women, as measured by number of cytokine-secreting cells. The observed increase of both IFN-gamma- and IL-4-secreting cells during normal pregnancy may be interpreted as a Th2-situation, since the effects of IL-4 predominate over the effects of IFN-gamma.
Nyckelord
- Pregnancy
- Th2
- Elispot
- MLC
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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