Sökning: onr:"swepub:oai:DiVA.org:liu-162087" >
Alzheimers Disease:...
Alzheimers Disease: Erythrocyte 2,3-diphosphoglycerate Content and Circulating Erythropoietin
-
- Jaremo, Petter (författare)
- Vrinnevi Hosp, Sweden; Karolinska Inst, Sweden
-
- Jejcic, Alenka (författare)
- Vrinnevi Hosp, Sweden; Karolinska Inst, Sweden
-
- Jelic, Vesna (författare)
- Karolinska Institutet,Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden
-
visa fler...
-
- Shahnaz, Tasmin (författare)
- Vrinnevi Hosp, Sweden; Karolinska Inst, Sweden
-
- Behbahani, Homira (författare)
- Karolinska Institutet,Karolinska Inst, Sweden
-
- Oweling, Magnus (författare)
- Vrinnevi Hosp, Sweden
-
- Winblad, Bengt (författare)
- Karolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
-
visa färre...
-
(creator_code:org_t)
- BENTHAM SCIENCE PUBL LTD, 2019
- 2019
- Engelska.
-
Ingår i: Current Alzheimer Research. - : BENTHAM SCIENCE PUBL LTD. - 1567-2050 .- 1875-5828. ; 16:9, s. 834-835
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.2...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: Alzheimers Disease (AD) features the accumulation of beta-amyloid in erythrocytes. The subsequent red cell damage may well affect their oxygen-carrying capabilities. 2,3-diphosphoglycerate (2,3-DPG) binds to the hemoglobin thereby promoting oxygen release. It is theorized that 2,3-DPG is reduced in AD and that the resulting hypoxia triggers erythropoietin (EPO) release. Methods amp; Objective: To explore this theory, we analyzed red cell 2,3-DPG content and EPO in AD, mild cognitive impairment, and the control group, subjective cognitive impairment. Results: We studied (i) 2,3-DPG in red cells, and (ii) circulating EPO in AD, and both markers were unaffected by dementia. Disturbances of these oxygen-regulatory pathways do not appear to participate in brain hypoxia in AD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Alzheimer; 2
- 3-diphosphoglycerate; erythrocytes; erythropoietin; beta-amyloid; cognitive impairment
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas