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Association Between...
Association Between Use of Primary-Prevention Implantable Cardioverter-Defibrillators and Mortality in Patients With Heart Failure A Prospective Propensity Score-Matched Analysis From the Swedish Heart Failure Registry
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- Schrage, Benedikt (författare)
- Karolinska Institutet,Karolinska Inst, Sweden; Univ Heart Ctr Hamburg, Germany; Univ Heart Ctr Hamburg, Germany
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- Uijl, Alicia (författare)
- Karolinska Institutet,Karolinska Inst, Sweden; Univ Utrecht, Netherlands
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- Benson, Lina (författare)
- Karolinska Institutet,Karolinska Inst, Sweden
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- Westermann, Dirk (författare)
- Univ Heart Ctr Hamburg, Germany
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- Stahlberg, Marcus (författare)
- Karolinska Institutet,Karolinska Inst, Sweden
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- Stolfo, Davide (författare)
- Karolinska Institutet,Karolinska Inst, Sweden; Azienda Sanitaria Univ Integrata Trieste, Italy
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- Dahlström, Ulf (författare)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
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- Linde, Cecilia (författare)
- Karolinska Institutet,Karolinska Inst, Sweden
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- Braunschweig, Frieder (författare)
- Karolinska Institutet,Karolinska Inst, Sweden
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- Savarese, Gianluigi (författare)
- Karolinska Institutet,Karolinska Inst, Sweden
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(creator_code:org_t)
- LIPPINCOTT WILLIAMS & WILKINS, 2019
- 2019
- Engelska.
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Ingår i: Circulation. - : LIPPINCOTT WILLIAMS & WILKINS. - 0009-7322 .- 1524-4539. ; 140:19, s. 1530-1539
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Most randomized trials on implantable cardioverter-defibrillator (ICD) use for primary prevention of sudden cardiac death in heart failure with reduced ejection fraction enrolled patients amp;gt;20 years ago. We investigated the association between ICD use and all-cause mortality in a contemporary heart failure with reduced ejection fraction cohort and examined relevant subgroups. Methods: Patients from the Swedish Heart Failure Registry fulfilling the European Society of Cardiology criteria for primary-prevention ICD were included. The association between ICD use and 1-year and 5-year all-cause and cardiovascular (CV) mortality was assessed by Cox regression models in a 1:1 propensity score-matched cohort and in prespecified subgroups. Results: Of 16 702 eligible patients, only 1599 (10%) had an ICD. After matching, 1305 ICD recipients were compared with 1305 nonrecipients. ICD use was associated with a reduction in all-cause mortality risk within 1 year (hazard ratio, 0.73 [95% CI, 0.60-0.90]) and 5 years (hazard ratio, 0.88 [95% CI, 0.78-0.99]). Results were consistent in all subgroups including patients with versus without ischemic heart disease, men versus women, those aged amp;lt;75 versus amp;gt;= 75 years, those with earlier versus later enrollment in the Swedish heart failure registry, and patients with versus without cardiac resynchronization therapy. Conclusions: In a contemporary heart failure with reduced ejection fraction population, ICD for primary prevention was underused, although it was associated with reduced short- and long-term all-cause mortality. This association was consistent across all the investigated subgroups. These results call for better implementation of ICD therapy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- defibrillators; implantable; heart failure; primary prevention; registries
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Schrage, Benedik ...
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Uijl, Alicia
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Benson, Lina
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Westermann, Dirk
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Stahlberg, Marcu ...
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Stolfo, Davide
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visa fler...
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Dahlström, Ulf
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Linde, Cecilia
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Braunschweig, Fr ...
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Savarese, Gianlu ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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Circulation
- Av lärosätet
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Linköpings universitet
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Karolinska Institutet