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An experimental stu...
An experimental study of methods for the analysis of variance components in the inference of laboratory information
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- Kallner, Anders (författare)
- Karolinska Institutet,Karolinska Univ Hosp, Sweden
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- Theodorsson, Elvar, Professor, 1953- (författare)
- Linköpings universitet,Avdelningen för klinisk kemi,Medicinska fakulteten,Region Östergötland, Klinisk kemi
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(creator_code:org_t)
- 2019-12-14
- 2020
- Engelska.
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Ingår i: Scandinavian Journal of Clinical and Laboratory Investigation. - : TAYLOR & FRANCIS LTD. - 0036-5513 .- 1502-7686. ; 80:1, s. 73-80
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Abstract
Ämnesord
Stäng
- Measurement uncertainty (MU) can be estimated and calculated by different procedures, representing different aspects and intended use. It is appropriate to distinguish between uncertainty determined under repeatability and reproducibility conditions, and to distinguish causes of variation using analysis of variance components. The intra-laboratory MU is frequently determined by repeated measurements of control material(s) of one or several concentrations during a prolonged period of time. We demonstrate, based on experimental results, how such results can be used to identify the repeatability, pure reproducibility and intra-laboratory variance as the sum of the two. Native patient material was used to establish repeatability using the Dahlberg formula for random differences between measurements and an expanded Dahlberg formula if a non-random difference, e.g. bias, was expected. Repeatability and reproducibility have different clinical relevance in intensive care compared to monitoring treatment of chronic diseases, comparison with reference intervals or screening.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Nyckelord
- Dahlberg error; repeatability; reproducibility; measurement uncertainty; variance components; analytical sensitivity
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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