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Restricted Canonica...
Restricted Canonical Correlation Analysis in Functional MRI-Validation and a Novel Thresholding Technique
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- Ragnehed, Mattias (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Medicinsk radiologi,Hälsouniversitetet,Röntgenkliniken i Linköping
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- Engström, Maria (författare)
- Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Medicinsk radiologi,Hälsouniversitetet
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- Knutsson, Hans (författare)
- Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Biomedicinsk instrumentteknik,Tekniska högskolan
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- Axelsson Söderfeldt, Birgitta (författare)
- Karolinska Institutet,Östergötlands Läns Landsting,Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Neurologi,Hälsouniversitetet,Neurologiska kliniken
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- Lundberg, Peter (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Medicinsk radiofysik,Medicinsk radiologi,Hälsouniversitetet,Radiofysikavdelningen,Röntgenkliniken i Linköping
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(creator_code:org_t)
- Wiley, 2009
- 2009
- Engelska.
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Ingår i: Journal of Magnetic Resonance Imaging. - : Wiley. - 1053-1807 .- 1522-2586. ; 29:1, s. 146-154
- Relaterad länk:
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http://urn.kb.se/res...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Purpose: To validate the performance of an analysis method for fMRI data based on restricted canonical correlation analysis (rCCA) and adaptive filtering, and to increase the usability of the method by introducing a new technique for significance estimation of rCCA maps.Materials and Methods: Activation data from a language task and also a resting state fMRI data were collected from eight volunteers. Data was analyzed using both the rCCA method and the General Linear Model (GLM). A modified Receiver Operating Characteristic (ROC) method was used to evaluate the performance of the different analysis methods. The area under a fraction of the ROC curve was used as a measure of performance. On resting state data the fraction of voxels above certain significance thresholds were used to evaluate the significance estimation method.Results: The rCCA method scored significantly higher on the area under the ROC curve than the GLM. The fraction of activated voxels determined by thresholding according to the introduced significance estimation technique showed good agreement with the thresholds selected.Conclusion: The rCCA method is an effective analysis tool for fMRI data and its usability is increased with the introduced significance estimation method.
Nyckelord
- fMRI
- GLM
- canonical correlation analysis
- thresholding
- significance
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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