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ER stress and neuro...
ER stress and neurodegenerative diseases
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- Lindholm, Dan (författare)
- Uppsala universitet,Institutionen för neurovetenskap,Neurobiologi
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- Wootz, Hanna (författare)
- Uppsala universitet,Institutionen för neurovetenskap,Neurobiologi
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- Korhonen, Laura (författare)
- Uppsala universitet,Linköpings universitet,Minerva Fdn, Inst Med Res, Biomedicum, FI-00290 Helsinki, Finland.,Institutionen för neurovetenskap,Neurobiologi
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(creator_code:org_t)
- 2006-01-06
- 2006
- Engelska.
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Ingår i: Cell Death and Differentiation. - Uppsala Univ, Biomed Ctr, Neurobiol Unit, Dept Neurosci, S-75123 Uppsala, Sweden. Biomedicum, Minerva Med Res Inst, Helsinki, Finland. : NATURE PUBLISHING GROUP. - 1350-9047 .- 1476-5403. ; 13:3, s. 385-392
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https://www.nature.c...
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Endoplasmic reticulum ( ER) stress is caused by disturbances in the structure and function of the ER with the accumulation of misfolded proteins and alterations in the calcium homeostasis. The ER response is characterized by changes in specific proteins, causing translational attenuation, induction of ER chaperones and degradation of misfolded proteins. In case of prolonged or aggravated ER stress, cellular signals leading to cell death are activated. ER stress has been suggested to be involved in some human neuronal diseases, such as Parkinson's disease, Alzheimer's and prion disease, as well as other disorders. The exact contributions to and casual effects of ER stress in the various disease processes, however, are not known. Here we will discuss the possible role of ER stress in neurodegenerative diseases, and highlight current knowledge in this field that may reveal novel insight into disease mechanisms and help to design better therapies for these disorders.
Nyckelord
- endoplasmic reticulum
- calcium
- caspase
- misfolded protein
- neurological disease
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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