Neurotrophic factors in cerebrospinal fluid and serum of patients with Rett syndrome

2016-07-02
Univ Helsinki, Hosp Children & Adolescents, Unit Child Neurol, Helsinki, Finland. Uppsala Univ, Ctr Biomed, Dept Dev Neurosci, Uppsala, Sweden. Univ Helsinki, Inst Biotechnol, Helsinki, Finland. Univ Kuopio, Childrens Hosp, Dept Child Neurol, FIN-70211 Kuopio, Finland.Sage Publications,1998
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Rett syndrome is now considered to be a neurodevelopmental disease. Its cause is unknown, but it has been suggested that neuronal growth factors and neurotransmitters play important roles. We measured levels of brain-derived neurotropic factor and glial cell line-derived neurotrophic factor in cerebrospinal fluid, and nerve growth factor and brain-derived neurotrophic factor in serum in child and adolescent patients with Rett syndrome. Levels of brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor in cerebrospinal fluid were below the limit of sensitivity of the methods used. Serum levels of nerve growth factor and brain-derived neurotrophic factor did not differ from control values. In Rett syndrome, the normal serum levels of nerve growth factor together and previously reported low levels of the factor in cerebrospinal fluid indicate that the latter may reflect low levels of nerve growth factor in the central nervous system.

Korhonen, LauraUniversity of Uppsala Uppsala, Sweden(Swepub:liu)lauko83 (författare)
Mikelsaar, MaitUniversity of Helsinki Helsinki, Finland (författare)
Lindholm, DanUniversity of Uppsala Uppsala, Sweden (författare)
Riikonen, RailiUniversity of Kuopio Kuopio, Finland (författare)
University of Helsinki Helsinki, FinlandUniversity of Uppsala Uppsala, Sweden (creator_code:org_t)

Ingår i:Journal of Child NeurologyUniv Helsinki, Hosp Children & Adolescents, Unit Child Neurol, Helsinki, Finland. Uppsala Univ, Ctr Biomed, Dept Dev Neurosci, Uppsala, Sweden. Univ Helsinki, Inst Biotechnol, Helsinki, Finland. Univ Kuopio, Childrens Hosp, Dept Child Neurol, FIN-70211 Kuopio, Finland. : Sage Publications13:9, s. 429-4330883-07381708-8283

Av författaren/redakt...: Vanhala, Raija; Korhonen, Laura; Mikelsaar, Mait; Lindholm, Dan; Riikonen, Raili

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