Sökning: onr:"swepub:oai:DiVA.org:liu-169056" > On the Definition o...
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000 | 04565naa a2200409 4500 | |
001 | oai:DiVA.org:liu-169056 | |
003 | SwePub | |
008 | 200907s2020 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1690562 URI |
024 | 7 | a https://doi.org/10.1093/gerona/glz2292 DOI |
040 | a (SwePub)liu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Linge, Jenniferu Linköpings universitet,Avdelningen för samhälle och hälsa,Medicinska fakulteten,AMRA Medical AB, Sweden4 aut0 (Swepub:liu)jenli83 |
245 | 1 0 | a On the Definition of Sarcopenia in the Presence of Aging and Obesity-Initial Results from UK Biobank |
264 | c 2019-10-23 | |
264 | 1 | b Oxford University Press,c 2020 |
338 | a electronic2 rdacarrier | |
500 | a Funding agencies: Medical Research CouncilMedical Research Council UK (MRC) [MC_PC_17228, MC_QA137853] Funding Source: Medline | |
520 | a BACKGROUND: Current consensus is to combine a functional measure with muscle quantity to assess/confirm sarcopenia. However, the proper body size adjustment for muscle quantity is debated and sarcopenia in obesity is not well described. Further, functional measures are not muscle-specific or sensitive to etiology, and can be confounded by, for example, fitness/pain. For effective detection/treatment/follow-up, muscle-specific biomarkers linked to function are needed.METHODS: Nine thousand six hundred and fifteen participants were included and current sarcopenia thresholds (EWGSOP2: DXA, hand grip strength) applied to investigate prevalence. Fat-tissue free muscle volume (FFMV) and muscle fat infiltration (MFI) were quantified through magnetic resonance imaging (MRI) and sex-and-body mass index (BMI)-matched virtual control groups (VCGs) were used to extract each participant's FFMV/height2 z-score (FFMVVCG). The value of combining FFMVVCG and MFI was investigated through hospital nights, hand grip strength, stair climbing, walking pace, and falls.RESULTS: Current thresholds showed decreased sarcopenia prevalence with increased BMI (underweight 8.5%/normal weight 4.3%/overweight 1.1%/obesity 0.1%). Contrary, the prevalence of low function increased with increasing BMI. Previously proposed body size adjustments (division by height2/weight/BMI) introduced body size correlations of larger/similar magnitude than before. VCG adjustment achieved normalization and strengthened associations with hospitalization/function. Hospital nights, low hand grip strength, slow walking pace, and no stair climbing were positively associated with MFI (p < .05) and negatively associated with FFMVVCG (p < .01). Only MFI was associated with falls (p < .01). FFMVVCG and MFI combined resulted in highest diagnostic performance detecting low function.CONCLUSIONS: VCG-adjusted FFMV enables proper sarcopenia assessment across BMI classes and strengthened the link to function. MFI and FFMV combined provides a more complete, muscle-specific description linked to function enabling objective sarcopenia detection. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
653 | a Dual-energy x-ray absorptiometry | |
653 | a Imaging biomarkers | |
653 | a Magnetic resonance imaging | |
653 | a Muscle fat infiltration | |
653 | a Sarcopenic obesity | |
700 | 1 | a Heymsfield, Steven B.u Pennington Biomedical Research Center, USA4 aut |
700 | 1 | a Dahlqvist Leinhard, Olof,d 1978-u Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,AMRA Medical AB, Sweden4 aut0 (Swepub:liu)oloda24 |
710 | 2 | a Linköpings universitetb Avdelningen för samhälle och hälsa4 org |
773 | 0 | t The journals of gerontology. Series A, Biological sciences and medical sciencesd : Oxford University Pressg 75:7, s. 1309-1316q 75:7<1309-1316x 1079-5006x 1758-535X |
856 | 4 | u https://liu.diva-portal.org/smash/get/diva2:1464637/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://academic.oup.com/biomedgerontology/article-pdf/75/7/1309/33403504/glz229.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-169056 |
856 | 4 8 | u https://doi.org/10.1093/gerona/glz229 |
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