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Structure-Antifouli...
Structure-Antifouling Activity Relationship and Molecular Targets of Bio-Inspired(thio)xanthones
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- Almeida, Joana R. (författare)
- Univ Porto, Portugal
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- Palmeira, Andreia (författare)
- Univ Porto, Portugal
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- Campos, Alexandre (författare)
- Univ Porto, Portugal
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visa fler...
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- Cunha, Isabel (författare)
- Univ Porto, Portugal
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- Freitas, Micaela (författare)
- Univ Porto, Portugal; Univ Geneva, Switzerland
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- Felpeto, Aldo Barreiro (författare)
- Univ Porto, Portugal
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- Turkina, Maria V, 1973- (författare)
- Linköpings universitet,Avdelningen för neurobiologi,Medicinska fakulteten
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- Vasconcelos, Vitor (författare)
- Univ Porto, Portugal
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- Pinto, Madalena (författare)
- Univ Porto, Portugal
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- Correia-da-Silva, Marta (författare)
- Univ Porto, Portugal
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- Sousa, Emilia (författare)
- Univ Porto, Portugal
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(creator_code:org_t)
- 2020-07-30
- 2020
- Engelska.
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Ingår i: Biomolecules. - : MDPI. - 2218-273X. ; 10:8
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- The development of alternative ecological and effective antifouling technologies is still challenging. Synthesis of nature-inspired compounds has been exploited, given the potential to assure commercial supplies of potential ecofriendly antifouling agents. In this direction, the antifouling activity of a series of nineteen synthetic small molecules, with chemical similarities with natural products, were exploited in this work. Six (4,5,7,10,15and17) of the tested xanthones showed in vivo activity toward the settlement ofMytilus galloprovincialislarvae (EC50: 3.53-28.60 mu M) and low toxicity to this macrofouling species (LC50> 500 mu M and LC50/EC50: 17.42-141.64), and two of them (7and10) showed no general marine ecotoxicity (Artemia salinamortality) after 48 h of exposure. Regarding the mechanism of action in mussel larvae, the best performance compounds4and5might be acting by the inhibition of acetylcholinesterase activity (in vitro and in silico studies), while7and10showed specific targets (proteomic studies) directly related with the mussel adhesive structure (byssal threads), given by the alterations in the expression ofMytiluscollagen proteins (PreCols) and proximal thread proteins (TMPs). A quantitative structure-activity relationship (QSAR) model was built with predictive capacity to enable speeding the design of new potential active compounds.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- xanthones; chemical synthesis; antifouling activity; invertebrates; molecular targets
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Almeida, Joana R ...
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Palmeira, Andrei ...
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Campos, Alexandr ...
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Cunha, Isabel
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Freitas, Micaela
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Felpeto, Aldo Ba ...
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visa fler...
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Turkina, Maria V ...
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Vasconcelos, Vit ...
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Pinto, Madalena
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Correia-da-Silva ...
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Sousa, Emilia
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Mikrobiologi ino ...
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Biomolecules
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Linköpings universitet