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Utility of intracer...
Utility of intracerebral theta burst electrical stimulation to attenuate interhemispheric inhibition and to promote motor recovery after cortical injury in an animal model
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- Barry, Melissa (författare)
- Department of Anatomy and the Brain Health Research Centre, University of Otago, Dunedin, New Zealand
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- Boddington, Laura (författare)
- Department of Anatomy and the Brain Health Research Centre, University of Otago, Dunedin, New Zealand
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- Igelström, Kajsa, 1980- (författare)
- Department of Anatomy and the Brain Health Research Centre, University of Otago, Dunedin, New Zealand
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- Gray, Jason (författare)
- Department of Anatomy and the Brain Health Research Centre, University of Otago, Dunedin, New Zealand
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- Shemmell, Jon (författare)
- School of Physical Education and the Brain Health Research Centre, University of Otago, Dunedin, New Zealand
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- Tseng, K-Y (författare)
- Department of Cellular & Molecular Pharmacology, The Chicago Medical School, Rosalind Franklin University of Medicine & Science, North Chicago, IL, USA
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- Oorschot, Dorothy (författare)
- Department of Anatomy and the Brain Health Research Centre, University of Otago, Dunedin, New Zealand
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- Reynolds, John (författare)
- Department of Anatomy and the Brain Health Research Centre, University of Otago, Dunedin, New Zealand
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(creator_code:org_t)
- Academic Press, 2014
- 2014
- Engelska.
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Ingår i: Experimental Neurology. - : Academic Press. - 0014-4886 .- 1090-2430. ; 261, s. 258-266
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Following a cerebral cortex injury such as stroke, excessive inhibition around the core of the injury is thought to reduce the potential for new motor learning. In part, this may be caused by an imbalance of interhemispheric inhibition (IHI); therefore, treatments that relieve the inhibitory drive from the healthy hemisphere to the peri-lesional area may enhance motor recovery. Theta burst stimulation delivered by transcranial magnetic stimulation has been tested as a means of normalizing IHI, but clinical results have been variable. Here we use a new rat model of synaptic IHI to demonstrate that electrical intracranial theta burst stimulation causes long-lasting changes in motor cortex excitability. Further, we show that contralateral intermittent theta burst stimulation (iTBS) blocks IHI via a mechanism involving cannabinoid receptors. Finally, we show that contralesional iTBS applied during recovery from cortical injury in rats improves the recovery of motor function. These findings suggest that theta burst stimulation delivered through implanted electrodes may be a promising avenue to explore for augmenting rehabilitation from brain injury.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Stroke
- Interhemispheric inhibition
- Motor cortex
- Rehabilitation
- Electrical stimulation
- Theta burst stimulation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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