Increased Risk of Squamous Cell Carcinoma of the Skin and Lymphoma Among 5,739 Patients with Bullous Pemphigoid: A Swedish Nationwide Cohort Study

Albadri, ZeyadLinköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten (författare)

Funding Agencies|Karolinska InstitutetKarolinska Institutet; Welander-Finsen Foundation; Sigurd and Elsa Goljes Foundation
Evidence about the association of bullous pemphigoid and the risk of cancer is conflicting. Patients diagnosed with bullous pemphigoid (n = 5,739) between 2005 and 2016 were matched with a control cohort from the general population (n = 17,168) to estimate their overall and specific risk of cancer. The risk of squamous cell cancer of the skin (cSCC) was increased in patients with bullous pemphigoid (hazard ratio (HR) 1.3; 95% confidence interval (CI) 1.1-1.6). The risk of lymphoma within one year after bullous pemphigoid diagnosis was also increased (HR 3.1; 95% CI 1.3-7.6). While overall cancer risk prior to diagnosis of bullous pemphigoid was similar in cases and controls (prevalence odds ratio (POR) 1.0; 95% CI 0.9-1.0), the risk of male genital cancer within one year prior to diagnosis of bullous pemphigoid was lower in cases (POR 0.4; 95% CI 0.2-0.8). Clinicians must be aware of the increased risk of cSCC and lymphoma in patients with bullous pemphigoid.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng
cancer; epidemiology; bullous pemphigoid; autoimmune diseases; malignancy; skin diseases

Thorslund, KristoferKarolinska Inst, Sweden (författare)
Habel, HenrikeKarolinska Institutet,Karolinska Inst, Sweden (författare)
Seifert, OliverLinköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Div Dermatol & Venereol, Sweden(Swepub:liu)olise96 (författare)
Gronhagen, CarinaLund Univ, Sweden (författare)
Linköpings universitetAvdelningen för cellbiologi (creator_code:org_t)

Ingår i:Acta Dermato-Venereologica: ACTA DERMATO-VENEREOLOGICA1000001-55551651-2057

Av författaren/redakt...: Albadri, Zeyad; Thorslund, Krist ...; Habel, Henrike; Seifert, Oliver; Gronhagen, Carin ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kirurgi

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