Sökning: onr:"swepub:oai:DiVA.org:liu-173475" >
Growth and developm...
Growth and development of islet autoimmunity and type 1 diabetes in children genetically at risk
-
- Nucci, Anita M. (författare)
- Georgia State Univ, GA 30303 USA
-
- Virtanen, Suvi M. (författare)
- Finnish Inst Hlth & Welf, Finland; Tampere Univ, Finland; Tampere Univ, Finland; Tampere Univ Hosp, Finland; Pirkanmaa Hosp Dist, Finland
-
- Cuthbertson, David (författare)
- Univ S Florida, FL 33620 USA
-
visa fler...
-
- Ludvigsson, Johnny (författare)
- Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus
-
- Einberg, Ulle (författare)
- Tallinn Childrens Hosp, Estonia
-
- Huot, Celine (författare)
- CHU Ste Justine, Canada
-
- Castano, Luis (författare)
- Univ Basque Country, Spain
-
- Aschemeier, Baerbel (författare)
- Childrens & Adolescents Hosp AUF DER BULT, Germany
-
- Becker, Dorothy J. (författare)
- Univ Pittsburgh, PA USA; UPMC Childrens Hosp Pittsburgh, PA USA
-
- Knip, Mikael (författare)
- Univ Helsinki, Finland; Helsinki Univ Hosp, Finland; Univ Helsinki, Finland; Folkhalsan Res Ctr, Finland; Tampere Univ Hosp, Finland
-
- Krischer, Jeffrey P. (författare)
- Univ S Florida, FL 33620 USA
-
visa färre...
-
(creator_code:org_t)
- 2021-01-21
- 2021
- Engelska.
-
Ingår i: Diabetologia. - : SPRINGER. - 0012-186X .- 1432-0428. ; 64:4, s. 826-835
- Relaterad länk:
-
https://link.springe...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Aims/hypothesis We aimed to evaluate the relationship between childhood growth measures and risk of developing islet autoimmunity (IA) and type 1 diabetes in children with an affected first-degree relative and increased HLA-conferred risk. We hypothesised that being overweight or obese during childhood is associated with a greater risk of IA and type 1 diabetes. Methods Participants in a randomised infant feeding trial (N = 2149) were measured at 12 month intervals for weight and length/height and followed for IA (at least one positive out of insulin autoantibodies, islet antigen-2 autoantibody, GAD autoantibody and zinc transporter 8 autoantibody) and development of type 1 diabetes from birth to 10-14 years. In this secondary analysis, Cox proportional hazard regression models were adjusted for birthweight and length z score, sex, HLA risk, maternal type 1 diabetes, mode of delivery and breastfeeding duration, and stratified by residence region (Australia, Canada, Northern Europe, Southern Europe, Central Europe and the USA). Longitudinal exposures were studied both by time-varying Cox proportional hazard regression and by joint modelling. Multiple testing was considered using family-wise error rate at 0.05. Results In the Trial to Reduce IDDM in the Genetically at Risk (TRIGR) population, 305 (14.2%) developed IA and 172 (8%) developed type 1 diabetes. The proportions of children overweight (including obese) and obese only were 28% and 9% at 10 years, respectively. Annual growth measures were not associated with IA, but being overweight at 2-10 years of life was associated with a twofold increase in the development of type 1 diabetes (HR 2.39; 95% CI 1.46, 3.92; p < 0.001 in time-varying Cox regression), and similarly with joint modelling. Conclusions/interpretation In children at genetic risk of type 1 diabetes, being overweight at 2-10 years of age is associated with increased risk of progression from multiple IA to type 1 diabetes and with development of type 1 diabetes, but not with development of IA. Future studies should assess the impact of weight management strategies on these outcomes. Graphical abstract
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Beta cell autoimmunity; Childhood growth; Genetic risk; Length; Type 1 diabetes; Weight
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Nucci, Anita M.
-
Virtanen, Suvi M ...
-
Cuthbertson, Dav ...
-
Ludvigsson, John ...
-
Einberg, Ulle
-
Huot, Celine
-
visa fler...
-
Castano, Luis
-
Aschemeier, Baer ...
-
Becker, Dorothy ...
-
Knip, Mikael
-
Krischer, Jeffre ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Endokrinologi oc ...
- Artiklar i publikationen
-
Diabetologia
- Av lärosätet
-
Linköpings universitet