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The SDR (short-chai...
The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative
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- Persson, Bengt (författare)
- Karolinska Institutet,Linköpings universitet,Bioinformatik,Tekniska högskolan
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- Kallberg, Yvonne (författare)
- Linköpings universitet,Bioinformatik,Tekniska högskolan
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- Bray, James E (författare)
- Oxford University
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- Bruford, Elspeth (författare)
- European Bioinformation Institute
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- Dellaporta, Stephen L (författare)
- Yale University
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- Favia, Angelo D (författare)
- University of Barcelona
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- Jornvall, Hans (författare)
- Karolinska Institutet
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- Kavanagh, Kathryn L (författare)
- Oxford University
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- Kedishvili, Natalia (författare)
- University of Alabama
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- Kisiela, Michael (författare)
- University Medical School Schleswig Holstein
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- Maserk, Edmund (författare)
- University Medical School Schleswig Holstein
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- Mindnich, Rebekka (författare)
- University of Pennsylvania
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- Orchard, Sandra (författare)
- University of Pennsylvania
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- Thornton, Janet M (författare)
- German Research Centre Environmental Health
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- Oppermann, Udo (författare)
- Oxford University
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Duarte, RG (författare)
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Penning, TM (författare)
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Adamski, J (författare)
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(creator_code:org_t)
- Elsevier BV, 2009
- 2009
- Engelska.
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Ingår i: Chemico-Biological Interactions. - : Elsevier BV. - 0009-2797 .- 1872-7786. ; 178:1-3, s. 94-98
- Relaterad länk:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Short-chain dehydrogenases/reductases (SDR) constitute one of the largest enzyme superfamilies with presently over 46,000 members. In phylogenetic comparisons, members of this superfamily show early divergence where the majority have only low pairwise sequence identity, although sharing common structural properties. The SDR enzymes are present in virtually all genomes investigated, and in humans over 70 SDR genes have been identified. In humans, these enzymes are involved in the metabolism of a large variety of compounds, including steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. It is now clear that SDRs represent one of the oldest protein families and contribute to essential functions and interactions of all forms of life. As this field continues to grow rapidly, a systematic nomenclature is essential for future annotation and reference purposes. A functional subdivision of the SDR superfamily into at least 200 SDR families based upon hidden Markov models forms a suitable foundation for such a nomenclature system, which we present in this paper using human SDRs as examples.
Nyckelord
- SDR
- Enzymes
- Nomenclature
- Bioinformatics
- Hidden Markov models
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Persson, Bengt
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Kallberg, Yvonne
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Bray, James E
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Bruford, Elspeth
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Dellaporta, Step ...
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Favia, Angelo D
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visa fler...
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Jornvall, Hans
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Kavanagh, Kathry ...
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Kedishvili, Nata ...
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Kisiela, Michael
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Maserk, Edmund
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Mindnich, Rebekk ...
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Orchard, Sandra
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Thornton, Janet ...
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Oppermann, Udo
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Duarte, RG
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Penning, TM
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Adamski, J
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visa färre...
- Artiklar i publikationen
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Chemico-Biologic ...
- Av lärosätet
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Linköpings universitet
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Karolinska Institutet