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- Fountoulakis, K.N.Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece (författare)
Modeling psychological function in patients with schizophrenia with the PANSS : An international multi-center study
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
- Cambridge University Press,2021
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:liu-174557
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-174557URI
- https://doi.org/10.1017/S1092852920001091DOI
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- Språk:engelska
- Sammanfattning på:engelska
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- Background.The aim of the current study was to explore the changing interrelationships among clinical variables through the stages of schizophrenia in order to assemble a comprehensive and meaningful disease model.Methods.Twenty-nine centers from 25 countries participated and included 2358 patients aged 37.21 ± 11.87 years with schizophrenia. Multiple linear regression analysis and visual inspection of plots were performed.Results.The results suggest that with progression stages, there are changing correlations among Positive and Negative Syndrome Scale factors at each stage and each factor correlates with all the others in that particular stage, in which this factor is dominant. This internal structure further supports the validity of an already proposed four stages model, with positive symptoms dominating the first stage, excitement/hostility the second, depression the third, and neurocognitive decline the last stage.Conclusions.The current study investigated the mental organization and functioning in patients with schizophrenia in relation to different stages of illness progression. It revealed two distinct “cores” of schizophrenia, the “Positive” and the “Negative,” while neurocognitive decline escalates during the later stages. Future research should focus on the therapeutic implications of such a model. Stopping the progress of the illness could demand to stop the succession of stages. This could be achieved not only by both halting the triggering effect of positive and negative symptoms, but also by stopping the sensitization effect on the neural pathways responsible for the development of hostility, excitement, anxiety, and depression as well as the deleterious effect on neural networks responsible for neurocognition.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Psykiatri hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Psychiatry hsv//eng
- long-term course; model; outcome; Schizophrenia; staging
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Dragioti, Elena,Ph.D.Linköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Stockholm Psychiatric Southwest Clinic, Karolinska Huddinge University Hospital, Sweden(Swepub:liu)eledr71 (författare)
- Theofilidis, A.T.3rd Department of Psychiatry, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece (författare)
- Wiklund, Tobias,1986-Linköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Stockholm Psychiatric Southwest Clinic, Karolinska Huddinge University Hospital, Huddinge, Sweden(Swepub:liu)tobwi28 (författare)
- Atmatzidis, XenofonLinköpings universitet,Institutionen för hälsa, medicin och vård,Medicinska fakulteten,Stockholm Psychiatric Southwest Clinic, Karolinska Huddinge University Hospital, Huddinge, Sweden(Swepub:liu)n/a (författare)
- Nimatoudis, I.3rd Department of Psychiatry, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece (författare)
- Thys, E.University Psychiatric Center, Katholieke Universiteit Leuven, Kortenberg, Belgium (författare)
- Wampers, M.University Psychiatric Center, Katholieke Universiteit Leuven, Kortenberg, Belgium; Department of Neurosciences, Katholieke Universiteit Leuven, Leuven, Belgium (författare)
- Hranov, L.University Multiprofile Hospital for Active Treatment in Neurology and Psychiatry sveti Naum, Sofia, Bulgaria (författare)
- Hristova, T.University Multiprofile Hospital for Active Treatment in Neurology and Psychiatry sveti Naum, Sofia, Bulgaria (författare)
- Aptalidis, D.University Multiprofile Hospital for Active Treatment in Neurology and Psychiatry sveti Naum, Sofia, Bulgaria (författare)
- Milev, R.Department of Psychiatry, Queens University, Providence Care Hospital, Kingston, ON, Canada (författare)
- Iftene, F.Department of Psychiatry, Queens University, Providence Care Hospital, Kingston, ON, Canada (författare)
- Spaniel, F.National Institute of Mental Health, Klecany, Czech Republic (författare)
- Knytl, P.National Institute of Mental Health, Klecany, Czech Republic (författare)
- Furstova, P.National Institute of Mental Health, Klecany, Czech Republic (författare)
- From, T.Department of Psychiatry, University of Turku, Turku, Finland (författare)
- Karlsson, H.Department of Psychiatry, University of Turku, Turku, Finland (författare)
- Walta, M.Department of Psychiatry, University of Turku, Turku, Finland (författare)
- Salokangas, R.K.R.Department of Psychiatry, University of Turku, Turku, Finland (författare)
- Azorin, J.-M.Department of Psychiatry, Sainte Marguerite University Hospital, Marseille, France; Timone Institute of Neuroscience, Marseille, France (författare)
- Bouniard, J.Department of Psychiatry, Sainte Marguerite University Hospital, Marseille, France; Timone Institute of Neuroscience, Marseille, France (författare)
- Montant, J.Department of Psychiatry, Sainte Marguerite University Hospital, Marseille, France; Timone Institute of Neuroscience, Marseille, France (författare)
- Juckel, G.Department of Psychiatry, Ruhr University Bochum, Bochum, Germany (författare)
- Haussleiter, I.S.Department of Psychiatry, Ruhr University Bochum, Bochum, Germany (författare)
- Douzenis, A.2nd Department of Psychiatry, National and Kapodistrian University of Athens, Athens, Greece (författare)
- Michopoulos, I.2nd Department of Psychiatry, National and Kapodistrian University of Athens, Athens, Greece (författare)
- Ferentinos, P.2nd Department of Psychiatry, National and Kapodistrian University of Athens, Athens, Greece (författare)
- Smyrnis, N.Department of Psychiatry, National and Kapodistrian University of Athens School of Medicine, Eginition Hospital, Athens, Greece (författare)
- Mantonakis, L.Department of Psychiatry, National and Kapodistrian University of Athens School of Medicine, Eginition Hospital, Athens, Greece (författare)
- Nemes, Z.Nyír Gyula Hospital, Budapest, Hungary (författare)
- Gonda, X.Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary (författare)
- Vajda, D.Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary (författare)
- Juhasz, A.Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary (författare)
- Shrivastava, A.Western University, London, ON, Canada (författare)
- Waddington, J.Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland (författare)
- Pompili, M.Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, SantAndrea Hospital, Sapienza University of Rome, Rome, Italy (författare)
- Comparelli, A.Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, SantAndrea Hospital, Sapienza University of Rome, Rome, Italy (författare)
- Corigliano, V.Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, SantAndrea Hospital, Sapienza University of Rome, Rome, Italy (författare)
- Rancans, E.Department of Psychiatry and Narcology, Riga Stradins University, Riga, Latvia (författare)
- Navickas, A.Department of Clinic of Psychiatric, Faculty of Medicine, Vilnius University, Vilnius, Lithuania; Department of Psychosocial Rehabilitation, Vilnius Mental Health Center, Vilnius, Lithuania; Department for Psychosis Treatment, Vilnius Mental Health Center, Vilnius, Lithuania (författare)
- Hilbig, J.Department of Clinic of Psychiatric, Faculty of Medicine, Vilnius University, Vilnius, Lithuania; Department of Psychosocial Rehabilitation, Vilnius Mental Health Center, Vilnius, Lithuania; Department for Psychosis Treatment, Vilnius Mental Health Center, Vilnius, Lithuania (författare)
- Bukelskis, L.Department of Clinic of Psychiatric, Faculty of Medicine, Vilnius University, Vilnius, Lithuania; Department of Psychosocial Rehabilitation, Vilnius Mental Health Center, Vilnius, Lithuania; Department for Psychosis Treatment, Vilnius Mental Health Center, Vilnius, Lithuania (författare)
- Stevovic, L.I.Clinical Department of Psychiatry, Clinical Centre of Montenegro, Podgorica, Montenegro; Department of Psychiatry, School of Medicine, University of Montenegro, Podgorica, Montenegro; Clinical Department of Neurology, Clinical Centre of Montenegro, Podgorica, Montenegro (författare)
- Vodopic, S.Clinical Department of Psychiatry, Clinical Centre of Montenegro, Podgorica, Montenegro; Department of Psychiatry, School of Medicine, University of Montenegro, Podgorica, Montenegro; Clinical Department of Neurology, Clinical Centre of Montenegro, Podgorica, Montenegro (författare)
- Esan, O.Department of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria (författare)
- Oladele, O.Department of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria (författare)
- Osunbote, C.Department of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria (författare)
- Rybakowski, J.K.Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland (författare)
- Wojciak, P.Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland (författare)
- Domowicz, K.Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland (författare)
- Figueira, M.L.Department of Psychiatry and Mental Health, Santa Maria University Hospital, Lisbon, Portugal (författare)
- Linhares, L.Department of Psychiatry and Mental Health, Santa Maria University Hospital, Lisbon, Portugal (författare)
- Crawford, J.Department of Psychiatry and Mental Health, Santa Maria University Hospital, Lisbon, Portugal (författare)
- Panfil, A.-L.University of Medicine and Pharmacy of Târgu Mures, Târgu Mures, Romania (författare)
- Smirnova, D.Department of Psychiatry, Samara Psychiatric Hospital, Inpatient Unit, Samara State Medical University, Samara, Russian Federation (författare)
- Izmailova, O.Department of Psychiatry, Samara Psychiatric Hospital, Inpatient Unit, Samara State Medical University, Samara, Russian Federation (författare)
- Lecic-Tosevski, D.Institute of Mental Health, Belgrade, Serbia; Serbian Academy of Sciences and Arts, Belgrade, Serbia (författare)
- Temmingh, H.Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa (författare)
- Howells, F.Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa (författare)
- Bobes, J.Department of Psychiatry, University of Oviedo, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Oviedo, Spain (författare)
- Garcia-Portilla, M.P.Department of Psychiatry, University of Oviedo, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Oviedo, Spain (författare)
- Garciá-Alvarez, L.Department of Psychiatry, University of Oviedo, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Oviedo, Spain (författare)
- Erzin, G.Psychiatry Department, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey (författare)
- Karada, H.Psychiatry Department, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey (författare)
- De, Sousa A.Department of Psychiatry, Lokmanya Tilak Municipal Medical College, Mumbai, India (författare)
- Bendre, A.Department of Psychiatry, Lokmanya Tilak Municipal Medical College, Mumbai, India (författare)
- Hoschl, C.National Institute of Mental Health, Klecany, Czech Republic (författare)
- Bredicean, C.University of Medicine, Pharmacy of Timisoara, Timisoara, Romania (författare)
- Papava, I.University of Medicine, Pharmacy of Timisoara, Timisoara, Romania (författare)
- Vukovic, O.Institute of Mental Health, School of Medicine, University of Belgrade, Belgrade, Serbia (författare)
- Pejuskovic, B.Department of Psychiatry, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland (författare)
- Russell, V.Department of Psychiatry, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland (författare)
- Athanasiadis, L.1st Department of Psychiatry, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece (författare)
- Konsta, A.1st Department of Psychiatry, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece (författare)
- Stein, D.Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa; MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa (författare)
- Berk, M.IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, Australia; Orygen, National Centre of Excellence in Youth Mental Health, Parkville, VIC, Australia; Centre for Youth Mental Health, Florey Institute for Neuroscience and Mental Health, Parkville, VIC, Australia; Department of Psychiatry, University of Melbourne, Parkville, VIC, Australia (författare)
- Dean, O.IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, Australia; Orygen, National Centre of Excellence in Youth Mental Health, Parkville, VIC, Australia; Centre for Youth Mental Health, Florey Institute for Neuroscience and Mental Health, Parkville, VIC, Australia; Department of Psychiatry, University of Melbourne, Parkville, VIC, Australia (författare)
- Tandon, R.Department of Psychiatry, University of Florida, Gainesville, FL, United States (författare)
- Kasper, S.Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria (författare)
- De, Hert M.University Psychiatric Center, Katholieke Universiteit Leuven, Kortenberg, Belgium; Department of Neurosciences, Katholieke Universiteit Leuven, Leuven, Belgium; Antwerp Health Law and Ethics Chair, AHLEC University, Antwerpen, Belgium (författare)
- Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, GreeceAvdelningen för prevention, rehabilitering och nära vård (creator_code:org_t)
Sammanhörande titlar
- Ingår i:CNS Spectrums: Cambridge University Press26:3, s. 290-2981092-85292165-6509
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- Fountoulakis, K. ...
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- Theofilidis, A.T ...
- Wiklund, Tobias, ...
- Atmatzidis, Xeno ...
- Nimatoudis, I.
- visa fler...
- Thys, E.
- Wampers, M.
- Hranov, L.
- Hristova, T.
- Aptalidis, D.
- Milev, R.
- Iftene, F.
- Spaniel, F.
- Knytl, P.
- Furstova, P.
- From, T.
- Karlsson, H.
- Walta, M.
- Salokangas, R.K. ...
- Azorin, J.-M.
- Bouniard, J.
- Montant, J.
- Juckel, G.
- Haussleiter, I.S ...
- Douzenis, A.
- Michopoulos, I.
- Ferentinos, P.
- Smyrnis, N.
- Mantonakis, L.
- Nemes, Z.
- Gonda, X.
- Vajda, D.
- Juhasz, A.
- Shrivastava, A.
- Waddington, J.
- Pompili, M.
- Comparelli, A.
- Corigliano, V.
- Rancans, E.
- Navickas, A.
- Hilbig, J.
- Bukelskis, L.
- Stevovic, L.I.
- Vodopic, S.
- Esan, O.
- Oladele, O.
- Osunbote, C.
- Rybakowski, J.K.
- Wojciak, P.
- Domowicz, K.
- Figueira, M.L.
- Linhares, L.
- Crawford, J.
- Panfil, A.-L.
- Smirnova, D.
- Izmailova, O.
- Lecic-Tosevski, ...
- Temmingh, H.
- Howells, F.
- Bobes, J.
- Garcia-Portilla, ...
- Garciá-Alvarez, ...
- Erzin, G.
- Karada, H.
- De, Sousa A.
- Bendre, A.
- Hoschl, C.
- Bredicean, C.
- Papava, I.
- Vukovic, O.
- Pejuskovic, B.
- Russell, V.
- Athanasiadis, L.
- Konsta, A.
- Stein, D.
- Berk, M.
- Dean, O.
- Tandon, R.
- Kasper, S.
- De, Hert M.
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