onr:"swepub:oai:DiVA.org:liu-17514"
Sökning: onr:"swepub:oai:DiVA.org:liu-17514" > 6-Thioguanine thera...
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
- Almer, SvenLinköpings universitet,Gastroenterologi och hepatologi,Hälsouniversitetet,Landstinget i Östergötland; Local Health Care Services in Central Östergötland; Department of Endocrinology and Gastroenterology; Närsjukvården i centrala Östergötland; Endokrin- och magtarmmedicinska kliniken (författare)
6-Thioguanine therapy in Crohns disease-Observational data in Swedish patients
- Artikel/kapitelEngelska2009
Förlag, utgivningsår, omfång ...
- Elsevier BV,2009
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:liu-17514
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-17514URI
- https://doi.org/10.1016/j.dld.2008.07.314DOI
- https://lup.lub.lu.se/record/1404940URI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
Ingår i deldatabas
- SwePubSwePub
Klassifikation
Anmärkningar
- Background and aims: Adverse events (AE) leading to discontinuation or dose-reduction of thiopurine therapy (TP) occur in 9-28% of patients with inflammatory bowel disease. 6-Thioguanine (6-TG) has been proposed as an alternative treatment in patients intolerant for azathioprine (AZA), but some concerns have been raised about drug safety. Methods: We evaluated in a prospective manner the tolerance and efficacy of 6-TG in 23 Crohns disease (CD) patients (13 men, median age 41 (19-65) years) with prior intolerance (n = 18) or resistance (It = 5) to AZA and/or 6-mercaptopurine (6-MP). In addition, eight patients had tried mycophenolate mofetil. Seventeen patients (74%) had undergone intestinal resection, often several times. Results: Patients were treated with a median daily dose of 40 mg 6-TG (range 20-60) for 259 (15-2272) days. Seven of 13 patients (54%) with active disease went into remission after 8 (4-26) weeks. Sixteen patients (70%) experienced AE that lead to discontinuation (n=10) after 85 (15-451) days or dose reduction (n=6) after 78 (10-853) days. Ten of 18 patients (56%) with prior TP-intolerance discontinued 6-TG treatment due to AE compared to none of five patients with TP-resistance (p=0.046). Of 13 patients that tolerated 6-TG, eight discontinued the drug due to therapeutic failure (n=5) or safety concerns (n=3). Eight patients (35%) continued treatment beyond 12 months. There was no significant difference in maximum thioguanine nucleotide levels between patients with AE leading to discontinuation/dose reduction and patients without AE, 652 (99-2488) vs. 551 (392-1574) pmol/8 x 10(8) RBC; p=0.80. Conclusions: In this cohort of CD patients with severe disease failing traditional thiopurine treatment, a small fraction (22%) had long-term benefit of 6-TG-treatment. 6-TG therapy seems to offer a limited therapeutic gain for patients intolerant to both AZA and 6-MP and other treatment options should be considered.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Gastroenterologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Gastroenterology and Hepatology hsv//eng
- 6-thioguanine
- Inflammatory bowel disease
- Thiopurine drugs
- Drug toxicity
- MEDICINE
- MEDICIN
- Thiopurine drugs
- 6-thioguanine
- Inflammatory bowel disease
- toxicity
- Drug
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Hjortswang, HenrikLinköpings universitet,Gastroenterologi och hepatologi,Hälsouniversitetet,Landstinget i Östergötland; Local Health Care Services in Central Östergötland; Department of Endocrinology and Gastroenterology; Närsjukvården i centrala Östergötland; Endokrin- och magtarmmedicinska kliniken(Swepub:liu)henhj44 (författare)
- Hindorf, UlfLund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-uhi (författare)
- Linköpings universitetGastroenterologi och hepatologi (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Digestive and Liver Disease: Elsevier BV41:3, s. 194-2001590-86581878-3562
Internetlänk
Hitta via bibliotek
- Digestive and Liver Disease (Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Almer, Sven
- Hjortswang, Henr ...
- Hindorf, Ulf
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- och Gastroenterologi
- Artiklar i publikationen
- Digestive and Li ...
- Av lärosätet
- Linköpings universitet
- Lunds universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
