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Population-based bo...
Population-based body-brain mapping links brain morphology with anthropometrics and body composition
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- Gurholt, Tiril P. (författare)
- Oslo Univ Hosp, Norway; Univ Oslo, Norway
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- Kaufmann, Tobias (författare)
- Oslo Univ Hosp, Norway; Univ Oslo, Norway; Univ Tubingen, Germany
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- Frei, Oleksandr (författare)
- Oslo Univ Hosp, Norway; Univ Oslo, Norway
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visa fler...
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- Alnaes, Dag (författare)
- Oslo Univ Hosp, Norway; Univ Oslo, Norway
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- Haukvik, Unn K. (författare)
- Oslo Univ Hosp, Norway; Univ Oslo, Norway
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- van der Meer, Dennis (författare)
- Oslo Univ Hosp, Norway; Univ Oslo, Norway; Maastricht Univ, Netherlands
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- Moberget, Torgeir (författare)
- Oslo Univ Hosp, Norway; Univ Oslo, Norway; Univ Oslo, Norway
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- OConnell, Kevin S. (författare)
- Oslo Univ Hosp, Norway; Univ Oslo, Norway
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- Dahlqvist Leinhard, Olof, 1978- (författare)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,AMRA Med, Linkoping, Sweden
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- Linge, Jennifer (författare)
- AMRA Med, Linkoping, Sweden
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- Simon, Rozalyn (författare)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,AMRA Med, Linkoping, Sweden
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- Smeland, Olav B. (författare)
- Oslo Univ Hosp, Norway; Univ Oslo, Norway
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- Sonderby, Ida E. (författare)
- Oslo Univ Hosp, Norway; Univ Oslo, Norway; Oslo Univ Hosp, Norway
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- Winterton, Adriano (författare)
- Oslo Univ Hosp, Norway; Univ Oslo, Norway
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- Steen, Nils Eiel (författare)
- Oslo Univ Hosp, Norway; Univ Oslo, Norway
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- Westlye, Lars T. (författare)
- Oslo Univ Hosp, Norway; Univ Oslo, Norway; Univ Oslo, Norway
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- Andreassen, Ole A. (författare)
- Oslo Univ Hosp, Norway; Univ Oslo, Norway
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(creator_code:org_t)
- 2021-05-18
- 2021
- Engelska.
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Ingår i: Translational Psychiatry. - : Springer Nature. - 2158-3188. ; 11:1
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Understanding complex body-brain processes and the interplay between adipose tissue and brain health is important for understanding comorbidity between psychiatric and cardiometabolic disorders. We investigated associations between brain structure and anthropometric and body composition measures using brain magnetic resonance imaging (MRI; n=24,728) and body MRI (n=4973) of generally healthy participants in the UK Biobank. We derived regional and global measures of brain morphometry using FreeSurfer and tested their association with (i) anthropometric measures, and (ii) adipose and muscle tissue measured from body MRI. We identified several significant associations with small effect sizes. Anthropometric measures showed negative, nonlinear, associations with cerebellar/cortical gray matter, and brain stem structures, and positive associations with ventricular volumes. Subcortical structures exhibited mixed effect directionality, with strongest positive association for accumbens. Adipose tissue measures, including liver fat and muscle fat infiltration, were negatively associated with cortical/cerebellum structures, while total thigh muscle volume was positively associated with brain stem and accumbens. Regional investigations of cortical area, thickness, and volume indicated widespread and largely negative associations with anthropometric and adipose tissue measures, with an opposite pattern for thigh muscle volume. Self-reported diabetes, hypertension, or hypercholesterolemia were associated with brain structure. The findings provide new insight into physiological body-brain associations suggestive of shared mechanisms between cardiometabolic risk factors and brain health. Whereas the causality needs to be determined, the observed patterns of body-brain relationships provide a foundation for understanding the underlying mechanisms linking psychiatric disorders with obesity and cardiovascular disease, with potential for the development of new prevention strategies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Gurholt, Tiril P ...
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Kaufmann, Tobias
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Frei, Oleksandr
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Alnaes, Dag
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Haukvik, Unn K.
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van der Meer, De ...
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visa fler...
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Moberget, Torgei ...
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OConnell, Kevin ...
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Dahlqvist Leinha ...
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Linge, Jennifer
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Simon, Rozalyn
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Smeland, Olav B.
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Sonderby, Ida E.
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Winterton, Adria ...
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Steen, Nils Eiel
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Westlye, Lars T.
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Andreassen, Ole ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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Translational Ps ...
- Av lärosätet
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Linköpings universitet