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Leishmania donovani...
Leishmania donovani lipophosphoglycan inhibits phagosomal maturation via action on membrane rafts
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- Winberg Tinnerfelt, Martin (författare)
- Linköpings universitet,Medicinsk mikrobiologi,Hälsouniversitetet
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- Holm, Åsa (författare)
- Linköpings universitet,Medicinsk mikrobiologi,Hälsouniversitetet,Linköping University, Linköping
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- Särndahl, Eva (författare)
- Örebro universitet,Linköpings universitet,Cellbiologi,Hälsouniversitetet,Institutionen för hälsovetenskap och medicin
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- Vinet, Adrien F (författare)
- INRS-Institut Armand-Frappier, Laval, QC, Canada
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- Descoteaux, Albert (författare)
- INRS-Institut Armand-Frappier, Laval, QC, Canada
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- Magnusson, Karl-Eric (författare)
- Linköpings universitet,Medicinsk mikrobiologi,Hälsouniversitetet,Linköping University, Linköping
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- Rasmusson, Birgitta (författare)
- Linköpings universitet,Medicinsk mikrobiologi,Hälsouniversitetet,Linköping University, Linköping
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- Lerm, Maria (författare)
- Linköpings universitet,Medicinsk mikrobiologi,Hälsouniversitetet,Linköping University, Linköping
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- Winberg, Martin E (författare)
- Linköping University, Linköping
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(creator_code:org_t)
- Paris, France : Elsevier BV, 2009
- 2009
- Engelska.
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Ingår i: Microbes and infection. - Paris, France : Elsevier BV. - 1286-4579 .- 1769-714X. ; 11:2, s. 215-222
- Relaterad länk:
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http://urn.kb.se/res...
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https://liu.diva-por... (primary) (Raw object)
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http://liu.diva-port...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Lipophosphoglycan (LPG), the major surface glycoconjugate on Leishmania donovani promastigotes, is crucial for the establishment of infection inside macrophages. LPG comprises a polymer of repeating Gal beta 1,4Man alpha-PO4 attached to a lysophosphatidylinositol membrane anchor. LPG is transferred from the parasite to the host macrophage membrane during phagocytosis and induces periphagosomal F-actin accumulation correlating with an inhibition of phagosomal maturation. The biophysical properties of LPG suggest that it may be intercalated into membrane rafts of the host-cell membrane. The aim of this study was to investigate if the effects of LPG on phagosomal maturation are mediated via action on membrane rafts. We show that LPG accumulates in rafts during phagocytosis of L. donovani and that disruption of membrane rafts abolished the effects of LPG on periphagosomal F-actin and phagosomal maturation, indicating that LPG requires intact membrane rafts to manipulate host-cell functions. We conclude that LPG associates with membrane rafts in the host cell and exert its actions on host-cell actin and phagosomal maturation through subversion of raft function.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Nyckelord
- Leishmania
- Lipophosphoglycan
- Membrane rafts
- Phagosomal maturation
- Actin
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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